Uridine cytidine kinases govern molnupiravir bioactivation and anti-SARS-CoV-2 activity.
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| Title: | Uridine cytidine kinases govern molnupiravir bioactivation and anti-SARS-CoV-2 activity. |
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| Authors: | Shu H; Department of Oncology-Pathology, Science for Life Laboratory (SciLifeLab), Karolinska Institutet, Stockholm, Sweden., Ludäscher JM; Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden., Sharma S; Department of Medical Biochemistry and Biophysics, Umeå University, Umeå, Sweden., Alam S; Department of Laboratory Medicine, Division of Clinical Physiology, Karolinska Institutet Huddinge, Huddinge, Sweden.; Department of Laboratory Medicine, Division of Clinical Physiology, Karolinska University Hospital, Huddinge, Sweden., Frank L; Department of Oncology-Pathology, Science for Life Laboratory (SciLifeLab), Karolinska Institutet, Stockholm, Sweden., Hutchinson ES; Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden., Tampere M; Department of Oncology-Pathology, Precision Cancer Medicine, Karolinska Institutet, Science for Life Laboratory, Solna, Sweden.; Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden., Lévêque C; Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden., van Kuilenburg ABP; Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, The Netherlands.; Department of Clinical Chemistry, Amsterdam UMC, Vrije Universiteit Amsterdam, Laboratory Genetic Metabolic Diseases, Amsterdam, The Netherlands., Valerie NCK; Department of Laboratory Medicine, Division of Clinical Physiology, Karolinska Institutet Huddinge, Huddinge, Sweden.; Department of Laboratory Medicine, Division of Clinical Physiology, Karolinska University Hospital, Huddinge, Sweden., Altun M; Department of Laboratory Medicine, Division of Clinical Physiology, Karolinska Institutet Huddinge, Huddinge, Sweden.; Department of Laboratory Medicine, Division of Clinical Physiology, Karolinska University Hospital, Huddinge, Sweden., Chabes A; Department of Medical Biochemistry and Biophysics, Umeå University, Umeå, Sweden., Stenmark P; Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden., Rudd SG; Department of Oncology-Pathology, Science for Life Laboratory (SciLifeLab), Karolinska Institutet, Stockholm, Sweden., Zhang SM; Department of Oncology-Pathology, Science for Life Laboratory (SciLifeLab), Karolinska Institutet, Stockholm, Sweden. |
| Source: | PLoS pathogens [PLoS Pathog] 2026 May 29; Vol. 22 (5), pp. e1014225. Date of Electronic Publication: 2026 May 29 (Print Publication: 2026). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1553-7374 |
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| DOI: | 10.1371/journal.ppat.1014225 |
