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Uridine cytidine kinases govern molnupiravir bioactivation and anti-SARS-CoV-2 activity.

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Title: Uridine cytidine kinases govern molnupiravir bioactivation and anti-SARS-CoV-2 activity.
Authors: Shu H; Department of Oncology-Pathology, Science for Life Laboratory (SciLifeLab), Karolinska Institutet, Stockholm, Sweden., Ludäscher JM; Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden., Sharma S; Department of Medical Biochemistry and Biophysics, Umeå University, Umeå, Sweden., Alam S; Department of Laboratory Medicine, Division of Clinical Physiology, Karolinska Institutet Huddinge, Huddinge, Sweden.; Department of Laboratory Medicine, Division of Clinical Physiology, Karolinska University Hospital, Huddinge, Sweden., Frank L; Department of Oncology-Pathology, Science for Life Laboratory (SciLifeLab), Karolinska Institutet, Stockholm, Sweden., Hutchinson ES; Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden., Tampere M; Department of Oncology-Pathology, Precision Cancer Medicine, Karolinska Institutet, Science for Life Laboratory, Solna, Sweden.; Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden., Lévêque C; Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden., van Kuilenburg ABP; Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, The Netherlands.; Department of Clinical Chemistry, Amsterdam UMC, Vrije Universiteit Amsterdam, Laboratory Genetic Metabolic Diseases, Amsterdam, The Netherlands., Valerie NCK; Department of Laboratory Medicine, Division of Clinical Physiology, Karolinska Institutet Huddinge, Huddinge, Sweden.; Department of Laboratory Medicine, Division of Clinical Physiology, Karolinska University Hospital, Huddinge, Sweden., Altun M; Department of Laboratory Medicine, Division of Clinical Physiology, Karolinska Institutet Huddinge, Huddinge, Sweden.; Department of Laboratory Medicine, Division of Clinical Physiology, Karolinska University Hospital, Huddinge, Sweden., Chabes A; Department of Medical Biochemistry and Biophysics, Umeå University, Umeå, Sweden., Stenmark P; Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden., Rudd SG; Department of Oncology-Pathology, Science for Life Laboratory (SciLifeLab), Karolinska Institutet, Stockholm, Sweden., Zhang SM; Department of Oncology-Pathology, Science for Life Laboratory (SciLifeLab), Karolinska Institutet, Stockholm, Sweden.
Source: PLoS pathogens [PLoS Pathog] 2026 May 29; Vol. 22 (5), pp. e1014225. Date of Electronic Publication: 2026 May 29 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Uridine cytidine kinases govern molnupiravir bioactivation and anti-SARS-CoV-2 activity.
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  Data: <searchLink fieldCode="AU" term="%22Shu+H%22">Shu H</searchLink>; Department of Oncology-Pathology, Science for Life Laboratory (SciLifeLab), Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Ludäscher+JM%22">Ludäscher JM</searchLink>; Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Sharma+S%22">Sharma S</searchLink>; Department of Medical Biochemistry and Biophysics, Umeå University, Umeå, Sweden.<br /><searchLink fieldCode="AU" term="%22Alam+S%22">Alam S</searchLink>; Department of Laboratory Medicine, Division of Clinical Physiology, Karolinska Institutet Huddinge, Huddinge, Sweden.; Department of Laboratory Medicine, Division of Clinical Physiology, Karolinska University Hospital, Huddinge, Sweden.<br /><searchLink fieldCode="AU" term="%22Frank+L%22">Frank L</searchLink>; Department of Oncology-Pathology, Science for Life Laboratory (SciLifeLab), Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Hutchinson+ES%22">Hutchinson ES</searchLink>; Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Tampere+M%22">Tampere M</searchLink>; Department of Oncology-Pathology, Precision Cancer Medicine, Karolinska Institutet, Science for Life Laboratory, Solna, Sweden.; Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Lévêque+C%22">Lévêque C</searchLink>; Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22van+Kuilenburg+ABP%22">van Kuilenburg ABP</searchLink>; Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, The Netherlands.; Department of Clinical Chemistry, Amsterdam UMC, Vrije Universiteit Amsterdam, Laboratory Genetic Metabolic Diseases, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Valerie+NCK%22">Valerie NCK</searchLink>; Department of Laboratory Medicine, Division of Clinical Physiology, Karolinska Institutet Huddinge, Huddinge, Sweden.; Department of Laboratory Medicine, Division of Clinical Physiology, Karolinska University Hospital, Huddinge, Sweden.<br /><searchLink fieldCode="AU" term="%22Altun+M%22">Altun M</searchLink>; Department of Laboratory Medicine, Division of Clinical Physiology, Karolinska Institutet Huddinge, Huddinge, Sweden.; Department of Laboratory Medicine, Division of Clinical Physiology, Karolinska University Hospital, Huddinge, Sweden.<br /><searchLink fieldCode="AU" term="%22Chabes+A%22">Chabes A</searchLink>; Department of Medical Biochemistry and Biophysics, Umeå University, Umeå, Sweden.<br /><searchLink fieldCode="AU" term="%22Stenmark+P%22">Stenmark P</searchLink>; Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Rudd+SG%22">Rudd SG</searchLink>; Department of Oncology-Pathology, Science for Life Laboratory (SciLifeLab), Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Zhang+SM%22">Zhang SM</searchLink>; Department of Oncology-Pathology, Science for Life Laboratory (SciLifeLab), Karolinska Institutet, Stockholm, Sweden.
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  Data: <searchLink fieldCode="JN" term="%22101238921%22">PLoS pathogens</searchLink> [PLoS Pathog] 2026 May 29; Vol. 22 (5), pp. e1014225. <i>Date of Electronic Publication: </i>2026 May 29 (<i>Print Publication: </i>2026).
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