Evolution-Oriented Modular Excision of Polyketide Synthases at a Splice Site of Enoylreductase Domain Yielded an Anti-Inflammatory Carboxyl Polyether.

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Title: Evolution-Oriented Modular Excision of Polyketide Synthases at a Splice Site of Enoylreductase Domain Yielded an Anti-Inflammatory Carboxyl Polyether.
Authors: Xu C; Department of Pharmacy, Ren Ji Hospital, College of Clinical Pharmacy, State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China., Hong LL; Department of Pharmacy, Ren Ji Hospital, College of Clinical Pharmacy, State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China., Xu J; Department of Pharmacy, Ren Ji Hospital, College of Clinical Pharmacy, State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China., Zang H; Department of Pharmacy, Ren Ji Hospital, College of Clinical Pharmacy, State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China., Peng W; Department of Pharmacy, Ren Ji Hospital, College of Clinical Pharmacy, State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China., Lin HW; Department of Pharmacy, Ren Ji Hospital, College of Clinical Pharmacy, State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.; Integrated Innovation Center for Marine Drugs, Shanghai Jiao Tong University, Shanghai 200127, China.; Marine Biomedical Science and Technology Innovation Platform of Lin-gang Special Area, Shanghai 201306, China., Zhou Y; Department of Pharmacy, Ren Ji Hospital, College of Clinical Pharmacy, State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.; Integrated Innovation Center for Marine Drugs, Shanghai Jiao Tong University, Shanghai 200127, China.
Source: Journal of natural products [J Nat Prod] 2026 Jun 26; Vol. 89 (6), pp. 1924-1931. Date of Electronic Publication: 2026 May 29.
Publication Type: Journal Article
Journal Info: Publisher: American Society of Pharmacognosy Country of Publication: United States NLM ID: 7906882 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6025 (Electronic) Linking ISSN: 01633864 NLM ISO Abbreviation: J Nat Prod Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1520-6025
DOI:10.1021/acs.jnatprod.6c00405