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Interactions between SSR504734, a selective glycine transporter type 1 inhibitor, and antiseizure drugs: pharmacodynamic and pharmacokinetic studies in mice.

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Title: Interactions between SSR504734, a selective glycine transporter type 1 inhibitor, and antiseizure drugs: pharmacodynamic and pharmacokinetic studies in mice.
Authors: Gapińska N; Biomedical Research Laboratory, Institute of Biological Sciences, Maria Curie-Skłodowska University, Akademicka 19, Lublin, 20-033, Poland; Doctoral School of Quantitative and Natural Sciences, Maria Curie-Skłodowska University, Weteranów 18, Lublin, 20-038, Poland., Wlaź P; Biomedical Research Laboratory, Institute of Biological Sciences, Maria Curie-Skłodowska University, Akademicka 19, Lublin, 20-033, Poland., Wyska E; Department of Pharmacokinetics and Physical Pharmacy, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Kraków, 30-688, Poland., Świerczek A; Department of Pharmacokinetics and Physical Pharmacy, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Kraków, 30-688, Poland., Kamiński K; Department of Medicinal Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Kraków, 30-688, Poland., Jakubiec M; Department of Medicinal Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Kraków, 30-688, Poland., Ciepiela K; Department of Medicinal Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Kraków, 30-688, Poland; Selvita S.A., Bobrzyńskiego 14, Kraków, 30-348, Poland., Abram M; Department of Medicinal Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Kraków, 30-688, Poland., Latacz G; Chair of Chemical Technology and Biotechnology of Drugs, Jagiellonian University Medical College, Medyczna 9, Kraków, 30-688, Poland., Poleszak E; Department of Applied and Social Pharmacy, Medical University of Lublin, Chodźki 1, Lublin, 20-093, Poland., Socała K; Biomedical Research Laboratory, Institute of Biological Sciences, Maria Curie-Skłodowska University, Akademicka 19, Lublin, 20-033, Poland. Electronic address: katarzyna.socala@mail.umcs.pl.
Source: Neuropharmacology [Neuropharmacology] 2026 May 28; Vol. 298, pp. 111046. Date of Electronic Publication: 2026 May 28.
Publication Type: Journal Article
Journal Info: Publisher: Pergamon Press Country of Publication: England NLM ID: 0236217 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7064 (Electronic) Linking ISSN: 00283908 NLM ISO Abbreviation: Neuropharmacology Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1873-7064
DOI:10.1016/j.neuropharm.2026.111046