Structural characterization of kappa-opioid receptor dimer in complex with two G proteins.

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Title: Structural characterization of kappa-opioid receptor dimer in complex with two G proteins.
Authors: Zhao Y; State Key Laboratory of Drug Research. Center for Structure and Function of Drug Targets, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China., Xu C; Cellular Signaling laboratory, International Research Center for Sensory Biology and Technology of MOST, Key Laboratory of Molecular Biophysics of MOE, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, 430074, China., Wang Y; State Key Laboratory of Drug Research. Center for Structure and Function of Drug Targets, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China., Shan H; State Key Laboratory of Drug Research. Center for Structure and Function of Drug Targets, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China., Wang J; Department of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, 27599, USA., Liu Y; Cellular Signaling laboratory, International Research Center for Sensory Biology and Technology of MOST, Key Laboratory of Molecular Biophysics of MOE, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, 430074, China., Luo X; Cellular Signaling laboratory, International Research Center for Sensory Biology and Technology of MOST, Key Laboratory of Molecular Biophysics of MOE, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, 430074, China., Li J; State Key Laboratory of Drug Research. Center for Structure and Function of Drug Targets, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China., Li M; Department of Pharmaceutical and Artificial-Intelligence Sciences, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, China.; Artificial Intelligence Clinical Research Center for drug discovery, Shanghai Key Laboratory of Flexible Medical Robotics, Tongren Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, China.; Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, China., Liu Y; Department of Pharmaceutical and Artificial-Intelligence Sciences, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, China., Wu K; State Key Laboratory of Drug Research. Center for Structure and Function of Drug Targets, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; The Shanghai Advanced Electron Microscope Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China., Roth BL; Department of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, 27599, USA., Huang XP; Department of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, 27599, USA., Xu HE; State Key Laboratory of Drug Research. Center for Structure and Function of Drug Targets, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. eric.xu@simm.ac.cn.; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China. eric.xu@simm.ac.cn.; University of Chinese Academy of Sciences, Beijing, 100049, China. eric.xu@simm.ac.cn., Liu J; Cellular Signaling laboratory, International Research Center for Sensory Biology and Technology of MOST, Key Laboratory of Molecular Biophysics of MOE, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, 430074, China. jfliu@mail.hust.edu.cn., Zhuang Y; State Key Laboratory of Drug Research. Center for Structure and Function of Drug Targets, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. youwen_zhuang@sjtu.edu.cn.; Department of Pharmaceutical and Artificial-Intelligence Sciences, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, China. youwen_zhuang@sjtu.edu.cn.; Artificial Intelligence Clinical Research Center for drug discovery, Shanghai Key Laboratory of Flexible Medical Robotics, Tongren Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, China. youwen_zhuang@sjtu.edu.cn.; Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, China. youwen_zhuang@sjtu.edu.cn.
Source: Nature communications [Nat Commun] 2026 May 29. Date of Electronic Publication: 2026 May 29.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-026-73615-x