NF1 loss in estrogen receptor-positive breast cancer induces osteoclast formation and immunosuppression to promote bone metastasis.

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Title: NF1 loss in estrogen receptor-positive breast cancer induces osteoclast formation and immunosuppression to promote bone metastasis.
Authors: Zhao Z; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA; Cancer & Cell Biology Graduate Program, Baylor College of Medicine, Houston, TX, USA., Zheng ZY; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA; Department of Medicine, Baylor College of Medicine, Houston, TX, USA., Lei JT; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA., Baik MJ; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA., Wu YH; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA; Cancer & Cell Biology Graduate Program, Baylor College of Medicine, Houston, TX, USA., Somes LK; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA; Cancer & Cell Biology Graduate Program, Baylor College of Medicine, Houston, TX, USA., Mosquera Paternina AF; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA., Harb OA; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA., Chang OA; DeBakey High School for Health Professions, Houston, TX, USA., Liu F; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA., Holt MV; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA., Wang J; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA., Bado I; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Wang H; Molecular and Cellular Biology Department, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Miles G; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA., Gugala Z; Department of Orthopaedic Surgery and Rehabilitation, University of Texas Medical Branch, Galveston, TX, USA., Anurag M; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA; Department of Medicine, Baylor College of Medicine, Houston, TX, USA., Elkhanany A; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA., Li Y; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA., Hoyos V; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA., Zhang XH; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA., Chang EC; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA. Electronic address: echang1@bcm.edu.
Source: Cancer letters [Cancer Lett] 2026 Sep 01; Vol. 655, pp. 218636. Date of Electronic Publication: 2026 May 29.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Ireland Country of Publication: Ireland NLM ID: 7600053 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7980 (Electronic) Linking ISSN: 03043835 NLM ISO Abbreviation: Cancer Lett Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1872-7980
DOI:10.1016/j.canlet.2026.218636