Mutational signatures of environmental carcinogens in human tissue organoids revealed by duplex sequencing.

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Title: Mutational signatures of environmental carcinogens in human tissue organoids revealed by duplex sequencing.
Authors: Kucab JE; Department of Analytical, Environmental and Forensic Sciences, School of Cancer and Pharmaceutical Sciences, King's College London, 150 Stamford Street, London SE1 9NH, UK. Electronic address: jill.kucab@kcl.ac.uk., Nandi SP; Department of Cellular and Molecular Medicine, UC San Diego, La Jolla, CA, USA., Al-Serori H; Department of Analytical, Environmental and Forensic Sciences, School of Cancer and Pharmaceutical Sciences, King's College London, 150 Stamford Street, London SE1 9NH, UK., Dunstone E; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK., Beck RSS; Department of Analytical, Environmental and Forensic Sciences, School of Cancer and Pharmaceutical Sciences, King's College London, 150 Stamford Street, London SE1 9NH, UK., Caipa Garcia AL; Department of Analytical, Environmental and Forensic Sciences, School of Cancer and Pharmaceutical Sciences, King's College London, 150 Stamford Street, London SE1 9NH, UK., Wilde EC; Department of Analytical, Environmental and Forensic Sciences, School of Cancer and Pharmaceutical Sciences, King's College London, 150 Stamford Street, London SE1 9NH, UK., Saeed S; Department of Cellular and Molecular Medicine, UC San Diego, La Jolla, CA, USA., Francies H; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK., Garnett MJ; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK., Fu B; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK., Yang F; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK., Saeb-Parsy K; Department of Surgery, University of Cambridge, NIHR Cambridge Biomedical Research Centre, Cambridge, UK., Huch M; Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany., Drost J; Princess Máxima Center for Pediatric Oncology, Oncode Institute, Utrecht 3584 CS, the Netherlands., Zilbauer M; Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, UK., Humphreys L; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK., Kisby G; Department of Biomedical Sciences, Western University of Health Sciences, Lebanon, OR 97355, USA., Arlt VM; Department of Analytical, Environmental and Forensic Sciences, School of Cancer and Pharmaceutical Sciences, King's College London, 150 Stamford Street, London SE1 9NH, UK., Stratton MR; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK., Alexandrov LB; Department of Cellular and Molecular Medicine, UC San Diego, La Jolla, CA, USA., Phillips DH; Department of Analytical, Environmental and Forensic Sciences, School of Cancer and Pharmaceutical Sciences, King's College London, 150 Stamford Street, London SE1 9NH, UK. Electronic address: david.phillips@kcl.ac.uk.
Source: Cell reports [Cell Rep] 2026 Jun 23; Vol. 45 (6), pp. 117406. Date of Electronic Publication: 2026 Jun 01.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2211-1247
DOI:10.1016/j.celrep.2026.117406