Necroptosis triggers inflammatory interferon signatures in patient-derived metastatic breast cancer organoids.
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| Title: | Necroptosis triggers inflammatory interferon signatures in patient-derived metastatic breast cancer organoids. |
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| Authors: | Wächtershäuser KN; Buchmann Institute for Molecular Life Sciences, Faculty of Biological Sciences (IZN), Goethe University Frankfurt am Main, Frankfurt am Main, Germany., Schneider JV; Buchmann Institute for Molecular Life Sciences, Faculty of Biological Sciences (IZN), Goethe University Frankfurt am Main, Frankfurt am Main, Germany., Gessner A; Department of Medicine II, Hematology/Oncology, Goethe University Frankfurt am Main, Frankfurt am Main, Germany., Andrieux G; Institute of Medical Bioinformatics and Systems Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Kur IM; Department for Immunity of Inflammation, Mannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Duschek N; Institute for Experimental Pediatric Hematology and Oncology, Goethe University Frankfurt am Main, Frankfurt am Main, Germany., Weigert A; Department for Immunity of Inflammation, Mannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Institute of Biochemistry I, Faculty of Medicine, Goethe University Frankfurt am Main, Frankfurt am Main, Germany.; German Cancer Consortium (DKTK) partner site Frankfurt/Mainz and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Frankfurt Cancer Institute (FCI), Frankfurt am Main, Germany., Boerries M; Institute of Medical Bioinformatics and Systems Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; German Cancer Consortium (DKTK), Partner site Freiburg, a partnership between DKFZ and Medical Center - University of Freiburg, Freiburg, Germany., Rieger MA; Department of Medicine II, Hematology/Oncology, Goethe University Frankfurt am Main, Frankfurt am Main, Germany.; German Cancer Consortium (DKTK) partner site Frankfurt/Mainz and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Frankfurt Cancer Institute (FCI), Frankfurt am Main, Germany., Stelzer EHK; Buchmann Institute for Molecular Life Sciences, Faculty of Biological Sciences (IZN), Goethe University Frankfurt am Main, Frankfurt am Main, Germany., Pampaloni F; Buchmann Institute for Molecular Life Sciences, Faculty of Biological Sciences (IZN), Goethe University Frankfurt am Main, Frankfurt am Main, Germany. fpampalo@bio.uni-frankfurt.de., van Wijk SJL; Institute for Experimental Pediatric Hematology and Oncology, Goethe University Frankfurt am Main, Frankfurt am Main, Germany. s.wijk@kinderkrebsstiftung-frankfurt.de.; German Cancer Consortium (DKTK) partner site Frankfurt/Mainz and German Cancer Research Center (DKFZ), Heidelberg, Germany. s.wijk@kinderkrebsstiftung-frankfurt.de.; University Cancer Centre Frankfurt (UCT), University Hospital Frankfurt, Goethe University Frankfurt am Main, Frankfurt am Main, Germany. s.wijk@kinderkrebsstiftung-frankfurt.de.; Institute for Physiology and Cell Biology, University of Veterinary Medicine, Hannover Foundation, Hannover, Germany. s.wijk@kinderkrebsstiftung-frankfurt.de. |
| Source: | Signal transduction and targeted therapy [Signal Transduct Target Ther] 2026 Jun 01; Vol. 11 (1). Date of Electronic Publication: 2026 Jun 01. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2059-3635 |
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| DOI: | 10.1038/s41392-026-02755-9 |
