TP53 deficiency in AML induces resistance to T-cell engagers through an immunosuppressive secretome.

Saved in:
Bibliographic Details
Title: TP53 deficiency in AML induces resistance to T-cell engagers through an immunosuppressive secretome.
Authors: Winter L; Laboratory for Translational Cancer Immunology, Gene Center, LMU Munich, Munich, Germany.; Department of Medicine III, LMU University Hospital, LMU Munich, Munich, Germany., Pawlowsky L; Laboratory for Translational Cancer Immunology, Gene Center, LMU Munich, Munich, Germany.; Department of Medicine III, LMU University Hospital, LMU Munich, Munich, Germany., Muth A; Laboratory for Translational Cancer Immunology, Gene Center, LMU Munich, Munich, Germany.; Department of Medicine III, LMU University Hospital, LMU Munich, Munich, Germany., Neumann AS; Laboratory for Translational Cancer Immunology, Gene Center, LMU Munich, Munich, Germany.; Department of Medicine III, LMU University Hospital, LMU Munich, Munich, Germany., White K; Laboratory for Translational Cancer Immunology, Gene Center, LMU Munich, Munich, Germany.; Department of Medicine III, LMU University Hospital, LMU Munich, Munich, Germany., Kazerani M; Laboratory for Translational Cancer Immunology, Gene Center, LMU Munich, Munich, Germany.; Department of Medicine III, LMU University Hospital, LMU Munich, Munich, Germany., Nixdorf D; Laboratory for Translational Cancer Immunology, Gene Center, LMU Munich, Munich, Germany.; Department of Medicine III, LMU University Hospital, LMU Munich, Munich, Germany., Brauchle B; Laboratory for Translational Cancer Immunology, Gene Center, LMU Munich, Munich, Germany.; Department of Medicine III, LMU University Hospital, LMU Munich, Munich, Germany., Rohrbacher L; Laboratory for Translational Cancer Immunology, Gene Center, LMU Munich, Munich, Germany.; Department of Medicine III, LMU University Hospital, LMU Munich, Munich, Germany., Hänel G; Laboratory for Translational Cancer Immunology, Gene Center, LMU Munich, Munich, Germany.; Department of Medicine III, LMU University Hospital, LMU Munich, Munich, Germany., Petrera A; Metabolomics and Proteomics Core, Helmholtz Zentrum München, Germany; Research Center for Environmental Health (GmbH), Neuherberg, Germany., Briem E; Anthropology and Human Genomics, Faculty of Biology, LMU Munich, Munich, Germany., Hoffmann GV; Division of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany., Janert T; Division of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany., Carlini E; Division of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany., Gottschlich A; Department of Medicine III, LMU University Hospital, LMU Munich, Munich, Germany.; Division of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany., Spiekermann K; Department of Medicine III, LMU University Hospital, LMU Munich, Munich, Germany., Straub T; Bioinformatics Unit, Biomedical Center, LMU Munich, Martinsried, Germany., Kischel R; Amgen Research (Munich) GmbH, Munich, Germany., Kobold S; Division of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany.; German Cancer Consortium (DKTK) Partner Site Munich, Munich, Germany.; German Center for Lung Research (DZL), Partner Site Munich, Munich, Germany., Andreeff M; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Buecklein VL; Laboratory for Translational Cancer Immunology, Gene Center, LMU Munich, Munich, Germany.; Department of Medicine III, LMU University Hospital, LMU Munich, Munich, Germany., Subklewe M; Laboratory for Translational Cancer Immunology, Gene Center, LMU Munich, Munich, Germany. Marion.Subklewe@med.uni-muenchen.de.; Department of Medicine III, LMU University Hospital, LMU Munich, Munich, Germany. Marion.Subklewe@med.uni-muenchen.de.; German Cancer Consortium (DKTK), Partner Site Munich and German Cancer Research Center (DKFZ), Heidelberg, Germany. Marion.Subklewe@med.uni-muenchen.de.; Bavarian Cancer Research Center (BZKF), Munich, Germany. Marion.Subklewe@med.uni-muenchen.de.
Source: Leukemia [Leukemia] 2026 Jun 01. Date of Electronic Publication: 2026 Jun 01.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-5551
DOI:10.1038/s41375-026-02991-6