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Mammary tumors-derived exosomes induce striatal NF-κB signaling, microglial reactivity, and anxiety/depression-like behaviors.

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Title: Mammary tumors-derived exosomes induce striatal NF-κB signaling, microglial reactivity, and anxiety/depression-like behaviors.
Authors: Han YY; School of Life Sciences, South China Normal University, Guangzhou 510631, China; Department of Radiology, Panyu Central Hospital, Guangzhou 511400, China; Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China. Electronic address: hanyy2025@m.scnu.edu.cn., Wu JC; School of Life Sciences, South China Normal University, Guangzhou 510631, China., Yang HM; Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China., Guo ZW; School of Life Sciences, South China Normal University, Guangzhou 510631, China., Gu CQ; School of Life Sciences, South China Normal University, Guangzhou 510631, China., Deng YW; School of Life Sciences, South China Normal University, Guangzhou 510631, China., Li HD; School of Life Sciences, South China Normal University, Guangzhou 510631, China., Huang MH; School of Life Sciences, South China Normal University, Guangzhou 510631, China., He XP; Department of Radiology, Panyu Central Hospital, Guangzhou 511400, China., Han QJ; Department of Radiology, Panyu Central Hospital, Guangzhou 511400, China., Kong H; School of Life Sciences, South China Normal University, Guangzhou 510631, China., Xu YQ; School of Life Sciences, South China Normal University, Guangzhou 510631, China., Yao J; School of Life Sciences, South China Normal University, Guangzhou 510631, China., Shan PH; School of Life Sciences, South China Normal University, Guangzhou 510631, China., Chen HY; Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China., Wen JY; School of Life Sciences, South China Normal University, Guangzhou 510631, China., Liu DX; Department of Radiology, Panyu Central Hospital, Guangzhou 511400, China., Tang YM; Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China. Electronic address: tangym@mail.sysu.edu.cn., Wang Z; School of Life Sciences, South China Normal University, Guangzhou 510631, China. Electronic address: wangz@m.scnu.edu.cn., Long C; School of Life Sciences, South China Normal University, Guangzhou 510631, China. Electronic address: longcheng@m.scnu.edu.cn.
Source: Brain, behavior, and immunity [Brain Behav Immun] 2026 Jun 01; Vol. 137, pp. 106841. Date of Electronic Publication: 2026 Jun 01.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8800478 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2139 (Electronic) Linking ISSN: 08891591 NLM ISO Abbreviation: Brain Behav Immun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Mammary tumors-derived exosomes induce striatal NF-κB signaling, microglial reactivity, and anxiety/depression-like behaviors.
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  Data: <searchLink fieldCode="AU" term="%22Han+YY%22">Han YY</searchLink>; School of Life Sciences, South China Normal University, Guangzhou 510631, China; Department of Radiology, Panyu Central Hospital, Guangzhou 511400, China; Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China. Electronic address: hanyy2025@m.scnu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Wu+JC%22">Wu JC</searchLink>; School of Life Sciences, South China Normal University, Guangzhou 510631, China.<br /><searchLink fieldCode="AU" term="%22Yang+HM%22">Yang HM</searchLink>; Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.<br /><searchLink fieldCode="AU" term="%22Guo+ZW%22">Guo ZW</searchLink>; School of Life Sciences, South China Normal University, Guangzhou 510631, China.<br /><searchLink fieldCode="AU" term="%22Gu+CQ%22">Gu CQ</searchLink>; School of Life Sciences, South China Normal University, Guangzhou 510631, China.<br /><searchLink fieldCode="AU" term="%22Deng+YW%22">Deng YW</searchLink>; School of Life Sciences, South China Normal University, Guangzhou 510631, China.<br /><searchLink fieldCode="AU" term="%22Li+HD%22">Li HD</searchLink>; School of Life Sciences, South China Normal University, Guangzhou 510631, China.<br /><searchLink fieldCode="AU" term="%22Huang+MH%22">Huang MH</searchLink>; School of Life Sciences, South China Normal University, Guangzhou 510631, China.<br /><searchLink fieldCode="AU" term="%22He+XP%22">He XP</searchLink>; Department of Radiology, Panyu Central Hospital, Guangzhou 511400, China.<br /><searchLink fieldCode="AU" term="%22Han+QJ%22">Han QJ</searchLink>; Department of Radiology, Panyu Central Hospital, Guangzhou 511400, China.<br /><searchLink fieldCode="AU" term="%22Kong+H%22">Kong H</searchLink>; School of Life Sciences, South China Normal University, Guangzhou 510631, China.<br /><searchLink fieldCode="AU" term="%22Xu+YQ%22">Xu YQ</searchLink>; School of Life Sciences, South China Normal University, Guangzhou 510631, China.<br /><searchLink fieldCode="AU" term="%22Yao+J%22">Yao J</searchLink>; School of Life Sciences, South China Normal University, Guangzhou 510631, China.<br /><searchLink fieldCode="AU" term="%22Shan+PH%22">Shan PH</searchLink>; School of Life Sciences, South China Normal University, Guangzhou 510631, China.<br /><searchLink fieldCode="AU" term="%22Chen+HY%22">Chen HY</searchLink>; Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.<br /><searchLink fieldCode="AU" term="%22Wen+JY%22">Wen JY</searchLink>; School of Life Sciences, South China Normal University, Guangzhou 510631, China.<br /><searchLink fieldCode="AU" term="%22Liu+DX%22">Liu DX</searchLink>; Department of Radiology, Panyu Central Hospital, Guangzhou 511400, China.<br /><searchLink fieldCode="AU" term="%22Tang+YM%22">Tang YM</searchLink>; Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China. Electronic address: tangym@mail.sysu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; School of Life Sciences, South China Normal University, Guangzhou 510631, China. Electronic address: wangz@m.scnu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Long+C%22">Long C</searchLink>; School of Life Sciences, South China Normal University, Guangzhou 510631, China. Electronic address: longcheng@m.scnu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%228800478%22">Brain, behavior, and immunity</searchLink> [Brain Behav Immun] 2026 Jun 01; Vol. 137, pp. 106841. <i>Date of Electronic Publication: </i>2026 Jun 01.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>8800478 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1090-2139 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2208891591%22">08891591 </searchLink><i>NLM ISO Abbreviation: </i>Brain Behav Immun <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.bbi.2026.106841
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              Text: 2026 Jun 01
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