Anti-asthma drug montelukast induces autistic behaviors via disrupting neuronal retinoic acid signaling.
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| Title: | Anti-asthma drug montelukast induces autistic behaviors via disrupting neuronal retinoic acid signaling. |
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| Authors: | Hao ZJ; Department of Colorectal Surgery and Oncology and School of Brain Science and Brain Medicine, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Institute of Science and Technology for Brain-Inspired Intelligence, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China.; Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China., Wu QH; Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.; Growth, Development, and Mental Health of Children and Adolescence Center, Children's Hospital of Chongqing Medical University, Chongqing, China., Li YL; Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China., Guo ZM; Institute for Regenerative Medicine, Medical Innovation Centre and State Key Laboratory of Cardiovascular Diseases, Shanghai Institute of Stem Cell Research and Clinical Translation, Shanghai East Hospital, National Stem Cell Translational Resource Centre & Ministry of Education Stem Cell Resource Centre, Frontier Science Centre for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, China., Li ZW; Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China., Wang G; Institute for Regenerative Medicine, Medical Innovation Centre and State Key Laboratory of Cardiovascular Diseases, Shanghai Institute of Stem Cell Research and Clinical Translation, Shanghai East Hospital, National Stem Cell Translational Resource Centre & Ministry of Education Stem Cell Resource Centre, Frontier Science Centre for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, China., Meng M; School of Data and Computer Science, Sun Yat-Sen University, Guangzhou, China., Yuan SL; Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China., Wufuer Y; Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China., Zhang MH; Institute for Regenerative Medicine, Medical Innovation Centre and State Key Laboratory of Cardiovascular Diseases, Shanghai Institute of Stem Cell Research and Clinical Translation, Shanghai East Hospital, National Stem Cell Translational Resource Centre & Ministry of Education Stem Cell Resource Centre, Frontier Science Centre for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, China., Chen J; Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China., Yang T; Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China., Chen MX; Institute for Regenerative Medicine, Medical Innovation Centre and State Key Laboratory of Cardiovascular Diseases, Shanghai Institute of Stem Cell Research and Clinical Translation, Shanghai East Hospital, National Stem Cell Translational Resource Centre & Ministry of Education Stem Cell Resource Centre, Frontier Science Centre for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, China., Zhu J; Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China., Qi-Hang W; Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China., Li Q; Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China., Yu SH; Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China.; University of Chinese Academy of Sciences, Beijing, China., Lu M; Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China., Xiong HY; Department of Pediatrics, Women and Children's Hospital of Chongqing Medical University, Chongqing, China.; Department of Pediatrics, Chongqing Health Center for Women and Children, Chongqing, China., Feng YR; Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China., Dong MQ; College of Public Health and Nursing, Shanghai Aurora College, Shanghai, China., Xu JH; Department of Biology, Stanford University, Stanford, CA, USA., Xu JL; School of Biological Sciences, University of California San Diego, San Diego, CA, USA., Chen L; Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.; Growth, Development, and Mental Health of Children and Adolescence Center, Children's Hospital of Chongqing Medical University, Chongqing, China., Yang HT; Institute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai, China., Miao JK; Department of Pediatrics, Women and Children's Hospital of Chongqing Medical University, Chongqing, China.; Department of Pediatrics, Chongqing Health Center for Women and Children, Chongqing, China., Zhu H; Institute of Pharmacology & Toxicology, Zhejiang Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China., Yang B; Institute of Pharmacology & Toxicology, Zhejiang Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.; School of Medicine, Hangzhou City University, Hangzhou, China., Zhao HY; School of Data and Computer Science, Sun Yat-Sen University, Guangzhou, China. zhaohy8@mail.sysu.edu.cn.; Department of Medical Research Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangzhou, China. zhaohy8@mail.sysu.edu.cn., Shi XM; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China; Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China. shixm@chinacdc.cn., Bian S; Institute for Regenerative Medicine, Medical Innovation Centre and State Key Laboratory of Cardiovascular Diseases, Shanghai Institute of Stem Cell Research and Clinical Translation, Shanghai East Hospital, National Stem Cell Translational Resource Centre & Ministry of Education Stem Cell Resource Centre, Frontier Science Centre for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, China. shan_bian@tongji.edu.cn.; National Health Commission Key Laboratory of Birth Defect Research and Prevention, Hunan Provincial Maternal and Child Health Care Hospital, University of South China, Changsha, China. shan_bian@tongji.edu.cn.; China Regional Research Center, International Center for Genetic Engineering and Biotechnology, Taizhou, China. shan_bian@tongji.edu.cn.; Jiangxi Province Key Laboratory of Organ Development and Epigenetics, Clinical Medical Research Center, Affiliated Hospital of Jinggangshan University, Medical Department of Jinggangshan University, Ji'an, China. shan_bian@tongji.edu.cn.; School of Life Science, Jinggangshan University, Ji'an, China. shan_bian@tongji.edu.cn., Li TY; Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China. tyli@vip.sina.com.; Growth, Development, and Mental Health of Children and Adolescence Center, Children's Hospital of Chongqing Medical University, Chongqing, China. tyli@vip.sina.com., Hu RG; Department of Colorectal Surgery and Oncology and School of Brain Science and Brain Medicine, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. coryhu@zju.edu.cn.; Medical Research and Innovation in Digestive System Tumors, Ministry of Education, Hangzhou, China. coryhu@zju.edu.cn.; Liangzhu Laboratory, MOE Frontier Science Center for Brain Science and Brain-machine Integration, State Key Laboratory of Brain-machine Intelligence, Zhejiang University, Hangzhou, China. coryhu@zju.edu.cn.; Brain Health Institute, National Center for Mental Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. coryhu@zju.edu.cn.; State Key Laboratory of Transvascular Implantation Devices, Hangzhou, China. coryhu@zju.edu.cn.; NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University, Hangzhou, China. coryhu@zju.edu.cn. |
| Source: | Signal transduction and targeted therapy [Signal Transduct Target Ther] 2026 Jun 02; Vol. 11 (1). Date of Electronic Publication: 2026 Jun 02. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2059-3635 |
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| DOI: | 10.1038/s41392-026-02665-w |
