Sphingosine kinase-2 inhibition promotes immunogenic differentiation of myeloid-derived suppressor cells through an Acetyl-CoA carboxylase-phosphatidylcholine axis.

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Title: Sphingosine kinase-2 inhibition promotes immunogenic differentiation of myeloid-derived suppressor cells through an Acetyl-CoA carboxylase-phosphatidylcholine axis.
Authors: Chakraborty P; Department of Pharmacology & Immunology, Medical University of South Carolina, Charleston, South Carolina, USA., Chatterjee S; Division of Cancer Biology and Inflammatory Disorder, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata, India., Kassir MF; Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, USA., Wofford W; Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, USA., Choi S; Department of Pharmacology & Immunology, Medical University of South Carolina, Charleston, South Carolina, USA., Oleinik N; Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, USA., Saatci O; Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, USA., Darawshi O; Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, USA., Das S; Department of Pharmacology & Immunology, Medical University of South Carolina, Charleston, South Carolina, USA., Oberhoeltzer N; Department of Pharmacology & Immunology, Medical University of South Carolina, Charleston, South Carolina, USA., Gautam A; Institute for Bioinformatics and Medical Informatics, University of Tübingen, Tübingen, Germany.; Max Planck Institute for Biology, Tübingen, Germany., Mills S; Department of Pharmacology & Immunology, Medical University of South Carolina, Charleston, South Carolina, USA., DeMass R; Public Health, Medical University of South Carolina, Charleston, South Carolina, USA., Hedley Z; Department of Pharmacology & Immunology, Medical University of South Carolina, Charleston, South Carolina, USA., Liu Y; Department of Pharmacology & Immunology, Medical University of South Carolina, Charleston, South Carolina, USA., Parikh RY; Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, USA., Paul S; Center for Health Science and Technology, JIS Institute of Advanced Studies and Research, JIS University, Kolkata, India., Seal S; Public Health, Medical University of South Carolina, Charleston, South Carolina, USA., Smith CD; Apogee Biotechnology Corporation, Hummelstown, USA., Lilly MB; Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA., Gangaraju VK; Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, USA., Peterson Y; Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, South Carolina, USA., Mehrotra M; Department of Surgery, Medical University of South Carolina, Charleston, South Carolina, USA., Hill E; Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, USA., Sahin O; Division of Cancer Biology and Inflammatory Disorder, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata, India., Leitinger N; Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, Virginia, USA., Rodriguez PC; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA., Ogretmen B; Division of Cancer Biology and Inflammatory Disorder, Council of Scientific and Industrial Research-Indian Institute of Chemical Biology, Kolkata, India., Mehrotra S; Department of Pharmacology & Immunology, Medical University of South Carolina, Charleston, South Carolina, USA. mehrotr@musc.edu.
Source: Nature communications [Nat Commun] 2026 Jun 02. Date of Electronic Publication: 2026 Jun 02.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-026-73827-1