Astaxanthin-metformin conjugate nanomicelles-loaded hydrogel reprograms macrophage metabolism via mitochondrion-targeted regulation for diabetic wound healing.

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Title: Astaxanthin-metformin conjugate nanomicelles-loaded hydrogel reprograms macrophage metabolism via mitochondrion-targeted regulation for diabetic wound healing.
Authors: Teng XN; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of General Dentistry and Emergency, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, China., Wang H; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of General Dentistry and Emergency, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, China., Zhu Y; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of General Dentistry and Emergency, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, China., Wang SC; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, China., Pan RL; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of General Dentistry and Emergency, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, China., Du C; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of General Dentistry and Emergency, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, China., Song RF; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of General Dentistry and Emergency, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, China., Zhang SS; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of General Dentistry and Emergency, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, China., Li JR; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of General Dentistry and Emergency, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, China., Zhang SB; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of General Dentistry and Emergency, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, China., Xu F; The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, China.; Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an, 710049, China., Zhang Q; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of General Dentistry and Emergency, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, China., Zhang M; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of General Dentistry and Emergency, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, China.
Source: Bioactive materials [Bioact Mater] 2026 May 24; Vol. 64, pp. 763-780. Date of Electronic Publication: 2026 May 24 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Ke Ai Publishing Country of Publication: China NLM ID: 101685294 Publication Model: eCollection Cited Medium: Internet ISSN: 2452-199X (Electronic) Linking ISSN: 2452199X NLM ISO Abbreviation: Bioact Mater Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2452-199X
DOI:10.1016/j.bioactmat.2026.05.031