DHODH Inhibitors Based on the Vidofludimus Scaffold Containing Carboxylic Acid Bioisosteres Exert a Superior Broad-Spectrum Antiviral Activity.

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Title: DHODH Inhibitors Based on the Vidofludimus Scaffold Containing Carboxylic Acid Bioisosteres Exert a Superior Broad-Spectrum Antiviral Activity.
Authors: Herrmann A; Immunic AG, 82166 Gräfelfing, Germany.; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany., Hahn F; Harald zur Hausen Institute of Virology, Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.; Institute of Virology, Ulm University Hospital, 89081 Ulm, Germany., Wangen C; Harald zur Hausen Institute of Virology, Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany., Wagner S; Harald zur Hausen Institute of Virology, Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany., Cordsmeier A; Harald zur Hausen Institute of Virology, Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany., Irrgang P; Harald zur Hausen Institute of Virology, Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany., Weil T; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany., Hunszinger V; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany., Groß R; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany., Heinen N; Department of Molecular and Medical Virology, Ruhr-University Bochum, 44801 Bochum, Germany., Pfaender S; Institute of Virology and Cell Biology, University of Luebeck, 23562 Lübeck, Germany.; Leibniz Institute of Virology, 20251 Hamburg, Germany., Westhoven S; Leibniz Institute of Virology, 20251 Hamburg, Germany., Reuter S; Department of Pulmonary Medicine, University Medical Center Essen - Ruhrlandklinik, 45239 Essen, Germany.; Mainz Lung Center, Pneumology Department, University Medical Center and Marienhaus Clinic, 55131 Mainz, Germany., Schedel M; Department of Pulmonary Medicine, University Medical Center Essen - Ruhrlandklinik, 45239 Essen, Germany.; Department of Pulmonary Medicine, University Medical Center Essen, 45239 Essen, Germany., Uhlig N; Fraunhofer-Institute for Cell Therapy and Immunology (IZI), Department of Infection Research and Diagnostics, Unit Preclinical Validation, 04103 Leipzig, Germany., Eberlein V; Fraunhofer-Institute for Cell Therapy and Immunology (IZI), Department of Infection Research and Diagnostics, Unit Preclinical Validation, 04103 Leipzig, Germany., Issmail L; Fraunhofer-Institute for Cell Therapy and Immunology (IZI), Department of Infection Research and Diagnostics, Unit Preclinical Validation, 04103 Leipzig, Germany., Grunwald T; Fraunhofer-Institute for Cell Therapy and Immunology (IZI), Department of Infection Research and Diagnostics, Unit Preclinical Validation, 04103 Leipzig, Germany., Klopfleisch R; Institute of Veterinary Pathology, Freie Universität Berlin, 14163 Berlin, Germany., Ensser A; Harald zur Hausen Institute of Virology, Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany., Tenbusch M; Harald zur Hausen Institute of Virology, Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany., Münch J; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany., Sparrer KMJ; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.; Neurovirology and Neuroinflammation, German Center for Neurodegenerative Diseases (DZNE), 89081 Ulm, Germany., Marschall M; Harald zur Hausen Institute of Virology, Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany., Kohlhof H; Immunic AG, 82166 Gräfelfing, Germany., Vitt D; Immunic AG, 82166 Gräfelfing, Germany., Gege C; Immunic AG, 82166 Gräfelfing, Germany.
Source: Journal of medicinal chemistry [J Med Chem] 2026 Jun 25; Vol. 69 (12), pp. 14255-14274. Date of Electronic Publication: 2026 Jun 03.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1520-4804
DOI:10.1021/acs.jmedchem.5c03715