Spatiotemporally programmed nanomedicine engineering to resolve conflicting immunosignals in triple-negative breast cancer.
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| Title: | Spatiotemporally programmed nanomedicine engineering to resolve conflicting immunosignals in triple-negative breast cancer. |
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| Authors: | Guo X; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Key Technologies and Application for Research and Development of New Anti-infective Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China., Zheng W; Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China., Song K; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Key Technologies and Application for Research and Development of New Anti-infective Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China., Zhang T; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Key Technologies and Application for Research and Development of New Anti-infective Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China., Luo Z; Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China., Hui Z; Department of VIP Medical Services, National Cancer Center/ National Clinical Research Center for Cancer/ Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China., Chen Q; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Key Technologies and Application for Research and Development of New Anti-infective Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China., Qin Y; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center of Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, China., Sun Y; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Key Technologies and Application for Research and Development of New Anti-infective Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China., Hu C; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Key Technologies and Application for Research and Development of New Anti-infective Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China., Tian X; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Key Technologies and Application for Research and Development of New Anti-infective Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China., Yang S; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Key Technologies and Application for Research and Development of New Anti-infective Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China., Ren L; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Key Technologies and Application for Research and Development of New Anti-infective Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China., Yu Q; China Pharmaceutical University, Nanjing, China., Yu H; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Key Technologies and Application for Research and Development of New Anti-infective Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China., Li B; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center of Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, China., He Y; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Key Technologies and Application for Research and Development of New Anti-infective Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China., Li Y; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Key Technologies and Application for Research and Development of New Anti-infective Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China., Pan M; University of California-Riverside, Riverside, CA, USA., Che Y; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Key Technologies and Application for Research and Development of New Anti-infective Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. ysche@imb.cams.cn., Nie G; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center of Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, China. niegj@nanoctr.cn., Jiang J; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Key Technologies and Application for Research and Development of New Anti-infective Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. jiangjiandong@imb.cams.cn.; Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. jiangjiandong@imb.cams.cn., Wang L; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Key Technologies and Application for Research and Development of New Anti-infective Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. wanglulu@imb.cams.cn. |
| Source: | Signal transduction and targeted therapy [Signal Transduct Target Ther] 2026 Jun 04; Vol. 11 (1). Date of Electronic Publication: 2026 Jun 04. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2059-3635 |
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| DOI: | 10.1038/s41392-026-02685-6 |
