Epigenetic control of telomeric RNA maintains heterochromatin in telomerase-driven cancers.
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| Title: | Epigenetic control of telomeric RNA maintains heterochromatin in telomerase-driven cancers. |
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| Authors: | Price JDW; Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada., Vizeacoumar FS; Department of Pathology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada., Abuhussein O; Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada.; College of Pharmacy, University of Saskatchewan, Saskatoon, SK, Canada., Maranda V; Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada., Zhang Y; Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada., Adachi H; Center for RNA Biology, Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY, USA., Nguyen K; Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada., Kyrylenko L; Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada., Rangel-Pozzo A; Cancer Care Manitoba Research Institute, Department of Physiology and Pathophysiology, University of Manitoba, Cancer Care Manitoba, Winnipeg, MB, Canada., Dong H; Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada., Gong L; Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada., Materi A; Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada., Walke P; Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada.; Department of Anatomy, Physiology, and Pharmacology, University of Saskatchewan and Cameco MS Neuroscience Research Centre, Saskatoon, SK, Canada., Ganapathysamy A; Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada., Denomy C; Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada.; Department of Anatomy, Physiology, and Pharmacology, University of Saskatchewan and Cameco MS Neuroscience Research Centre, Saskatoon, SK, Canada., Freywald T; Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada., Dahiya R; Department of Pathology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada., Elhasasna H; College of Pharmacy, University of Saskatchewan, Saskatoon, SK, Canada., Saxena A; Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada., Vizeacoumar JP; Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada., Patel H; Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada., Rajamanickam K; Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada., de Oliveira DM; Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada., Lazell-Wright M; Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada., Morales AM; Department of Pathology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada., Aggarwal A; Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Saskatchewan, Saskatoon, SK, Canada., Xu JL; Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada., Alli N; Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada., Munhoz EP; Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada., Gao P; Agriculture and Agri-Food Canada, Saskatoon Research and Development Centre, Saskatoon, SK, Canada., Salsman J; Department of Pathology, Dalhousie University, Halifax, NS, Canada., Dahiya DK; Department of Pathology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada., Kola NS; Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, SK, Canada., Gonzalez-Lopez C; Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada., Thibault P; Department of Anatomy, Physiology, and Pharmacology, University of Saskatchewan and Cameco MS Neuroscience Research Centre, Saskatoon, SK, Canada., Levin M; Department of Anatomy, Physiology, and Pharmacology, University of Saskatchewan and Cameco MS Neuroscience Research Centre, Saskatoon, SK, Canada., Dellaire G; Department of Pathology, Dalhousie University, Halifax, NS, Canada., Jette N; Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, SK, Canada., Groot G; Department of Surgery, University of Saskatchewan, Saskatoon, SK, Canada., Köbel M; Department of Pathology, University of Calgary, Calgary, AB, Canada., Lee CH; Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada., Hopkins L; College of Pharmacy, University of Saskatchewan, Saskatoon, SK, Canada., Krishnan A; Department of Anatomy, Physiology, and Pharmacology, University of Saskatchewan and Cameco MS Neuroscience Research Centre, Saskatoon, SK, Canada., Ahmed S; Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada., Eskiw C; Department of Food and Bioproduct Sciences, University of Saskatchewan, Saskatoon, SK, Canada., Barakat KH; Faculty of Pharmacy and Pharmaceutical Sciences, Li Ka Shing Institute of Virology, University of Alberta, Edmonton, AB, Canada., Thakur A; Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, SK, Canada., Wu Y; Department of Biochemistry, Microbiology and Immunology, University of Saskatchewan, Saskatoon, SK, Canada., DePinho RA; Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Mai S; Cancer Care Manitoba Research Institute, Department of Physiology and Pathophysiology, University of Manitoba, Cancer Care Manitoba, Winnipeg, MB, Canada., Yu YT; Center for RNA Biology, Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY, USA. yitao_yu@urmc.rochester.edu., Wong JMY; Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada. judy.wong@ubc.ca., Freywald A; Department of Pathology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada. andrew.freywald@usask.ca., Vizeacoumar FJ; Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada. franco.vizeacoumar@usask.ca.; Cancer Research Department, Saskatchewan Cancer Agency, Saskatoon, Canada. franco.vizeacoumar@usask.ca. |
| Source: | Signal transduction and targeted therapy [Signal Transduct Target Ther] 2026 Jun 04; Vol. 11 (1). Date of Electronic Publication: 2026 Jun 04. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2059-3635 |
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| DOI: | 10.1038/s41392-026-02750-0 |
