Altered neurodevelopmental trajectories of brain structure in Tourette syndrome and Chronic Tic Disorders.

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Title: Altered neurodevelopmental trajectories of brain structure in Tourette syndrome and Chronic Tic Disorders.
Authors: Jin Y; Department of Biological Science, Purdue University, West Lafayette, USA., Guo Y; Department of Biological Science, Purdue University, West Lafayette, USA., Koller JM; Departments of Psychiatry, Neurology, Radiology and Neuroscience, Washington University in St. Louis, USA., Grossen SC; Departments of Psychiatry, Neurology, Radiology and Neuroscience, Washington University in St. Louis, USA., Uhlmann A; Department of Child and Adolescent Psychiatry, TU Dresden, Dresden, Germany., Forde NJ; Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, Netherlands., Zouki JJ; Centre for Social and Early Emotional Development and School of Psychology, Deakin University, Burwood, Australia., Torrecuso R; Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany., Mueller K; Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.; Department of Neurology, Charles University, First Faculty of Medicine and General University Hospital, Prague, Czech Republic., Martin-Rodriguez JF; Unidad de Trastornos del Movimiento, Servicio de Neurología, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, 41013 Seville, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, 28029 Madrid, Spain.; Departamento de Psicología Experimental, Universidad de Sevilla, 41018 Seville, Spain., Franco-Rosado P; Unidad de Trastornos del Movimiento, Servicio de Neurología, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, 41013 Seville, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, 28029 Madrid, Spain.; Departamento de Psicología Experimental, Universidad de Sevilla, 41018 Seville, Spain., Grothe M; Instituto de Biomedicina de Sevilla (IBiS), Spain., Cramer C; Department of Psychiatry, Hannover University Medical School, Hannover, Germany., Büning AK; Department of Psychiatry, Hannover University Medical School, Hannover, Germany., Eichele H; Department of Biological and Medical Psychology, University of Bergen, Norway., Palmucci S; Department of Medical Surgical Sciences and Advanced Technologies, Radiology Unit 1, University of Catania, Italy., Prato A; Deparment of Clinical and Experimental Medicine, Child and Adolescent Neurology and Psichiatry, University of Catania, Italy., Saia F; Child Neuropsychiatry Unit, Department of Clinical and Experimental Medicine, School of Medicine, University of Catania, Italy., Tommasin S; Department of Human Neurosciences, Sapienza University of Rome, Italy., Conte G; Department of Human Neurosciences, Sapienza University of Rome, Italy., Schindlbeck KA; Department of Psychiatry and Psychotherapy, LMU University Hospital, LMU Munich, Germany., Ganos C; Charité, University Medicine Berlin, Germany., Zimmermann S; Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Germany.; Institute of Neuroscience and Medicine 4, Forschungszentrum Jülich GmbH, Germany.; JARA BRAIN - Translational Medicine, Germany., Veselinovic T; Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Germany., Worbe Y; Department of Clinical Neurophysiology, Sorbonne Université, APHP - Saint Antoine Hospital, Paris France.; Paris Brain Institute - Salpetriere Hospital, Paris, France., Hartmann A; Department of Neurology, Pitié-Salpêtrière Hospital, Paris, France., Topaloudi A; Department of Biological Science, Purdue University, West Lafayette, USA., Kaka M; Department of Biological Science, Purdue University, West Lafayette, USA., Chen G; Department of Biological Science, Purdue University, West Lafayette, USA., Zhong Q; Department of Biological Science, Purdue University, West Lafayette, USA., Zhang Y; Department of Biological Science, Purdue University, West Lafayette, USA., Szejko N; Department of Child Psychiatry, Babinski Hospital, Lodz, Poland.; Department of Experimental and Clinical Pharmacology, Center for Preclinical Research and Technology CEPT, Medical University of Warsaw, Warsaw, Poland., Janik P; Department of Neurology, Medical University of Warsaw, Warsaw, Poland., Debes NM; Department of Pediatrics, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Tumer Z; Department of Clinical Genetics, Kennedy Center, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Wolańczyk T; Department of Child Psychiatry, Medical University of Warsaw, Warsaw, Poland., Heiman GA; Department of Genetics and the Human Genetics Institute of New Jersey, Rutgers University, Piscataway, NJ 08854, USA., Stefansson H; Amgen deCODE genetics, Iceland., Ask H; PsychGen Center for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Norway., Andreassen O; Centre for Precision Psychiatry, University of Oslo, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway., Børglum AD; Department of Biomedicine - Human Genetics, Aarhus University, Aarhus, Denmark.; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Denmark.; Center for Genomics and Personalized Medicine, Aarhus, Denmark., Buxbaum JD; Icahn School of Medicine at Mount Sinai, Department of Psychiatry, New York, NY, USA., Corfield EC; PsychGen Center for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Norway.; Psychiatric Genetic Epidemiology Group, Research Department, Lovisenberg Diaconal Hospital, Norway.; MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, UK., Daly M; Harvard Medical School, USA.; Massachusetts General Hospital, USA., Grice DE; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Mataix-Cols D; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden., Palotie A; Institute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, Helsinki, Finland., Rück C; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden., Halvorsen MW; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Davis LK; Professor of Medicine, Department of Medicine, Division of Data Driven and Digital Medicine, USA.; Windreich Department of AI and Human Health, Icahn School of Medicine at Mount Sinai, USA.; Charles Bronfman Institute for Personalized Medicine, USA.; Adjunct Associate Professor of Medicine, Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, USA., Crowley JJ; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Mattheisen M; Department of Community Health and Epidemiology and Faculty of Computer Science, Dalhousie University, Halifax, Nova Scotia, Canada.; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Yu D; Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Mathews CA; University of Florida, Department of Psychiatry, Genetics Institute, Center for OCD, Anxiety and Related Disorders, Evelyn F and William L McKnight Brain Institute, Gainesville, FL, USA., Scharf JM; Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA., Stein DJ; SAMRC Unit on Risk & Resilience in Mental Disorders, Dept of Psychiatry & Neuroscience Institute, University of Cape Town, South Africa., Neuner I; Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Germany.; Institute of Neuroscience and Medicine 4, Forschungszentrum Jülich GmbH, Germany.; JARA BRAIN - Translational Medicine, Germany., Musil R; Ludwig-Maximilians-University of Munich, Germany., Cardona F; Department of Human Neurosciences, Sapienza University of Rome, Italy., Cath D; University of Groningen, university Medical Center Groningen, department of Psychiatry &Drenthe MHC, Groningen, the Netherlands., Veltman DJ; Dept. of Psychiatry, Amsterdam University Medical Center, location VUmc, Amsterdam, The Netherlands., Silk TJ; Centre for Social and Early Emotional Development and School of Psychology, Deakin University, Burwood, Australia.; Developmental Imaging, Murdoch Children's Research Institute, Melbourne, VIC, Australia., Munchau A; Institute of Systems Motor Science, University of Lübeck, Lübeck, Germany.; Centre for Rare Diseases, University Hospital Schleswig-Holstein, Lübeck, Germany., Verrel J; Unidad de Trastornos del Movimiento, Servicio de Neurología, Instituto de Biomedicina de Sevilla, IBiS/Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain., Brandt VC; Department of Psychology, University of Southampton, UK., Hershey T; Kennedy Krieger Institute, Baltimore MD, USA., Greene DJ; Department of Cognitive Science, University of California, San Diego, La Jolla, CA, United States., Schlaggar BL; Kennedy Krieger Institute, Baltimore MD, USA.; Departments of Neurology and Pediatrics, Johns Hopkins University School of Medicine, Baltimore MD 21205, USA., Buitelaar J; Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, Netherlands., Franke B; Departments of Genetics and of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical CentreRadboud University, The Netherlands., Thomopoulos S; Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, USA., Rizzo R; Deparment of Clinical and Experimental Medicine, Child and Adolescent Neurology and Psichiatry, University of Catania, Italy., Dietrich A; University of Groningen, University Medical Center Groningen, Department of Child and Adolescent Psychiatry & Accare Child Study Center, Groningen, Netherlands., Hoekstra PJ; University of Groningen, University Medical Center Groningen, Department of Psychiatry & Accare Child Study Center, Groningen, Netherlands., Mir P; Unidad de Trastornos del Movimiento, Servicio de Neurología, Instituto de Biomedicina de Sevilla, IBiS/Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain.; Departamento de Medicina, Facultad de Medicina, Universidad de Sevilla, Seville, Spain., Roessner V; Department of Child and Adolescent Psychiatry, TU Dresden, Dresden, Germany., van den Heuvel OA; Dept. Psychiatry, Dept. Anatomy & Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, The Netherlands., Mueller-Vahl K; Department of Psychiatry, Hannover University Medical School, Hannover, Germany., Möller H; Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany., Jahanshad N; Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, USA., Thompson PM; Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, USA., Black KJ; Departments of Psychiatry, Neurology, Radiology and Neuroscience, Washington University in St. Louis, USA., Paschou P; Department of Biological Science, Purdue University, West Lafayette, USA.
Corporate Authors: members of the Tourette International TS-EUROTRAIN/TSGeneSEE, TAA Neuroimaging Consortium, Collaborative Genetics consortium, TAAICG, EMTICS, ENIGMA-TS Working Group
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2026 May 20. Date of Electronic Publication: 2026 May 20.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
DOI:10.64898/2026.05.16.26353368