The single nucleotide polymorphism rs1053230 modulates kynurenine 3-monooxygenase stability and is associated with cognitive and mood phenotypes.

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Title: The single nucleotide polymorphism rs1053230 modulates kynurenine 3-monooxygenase stability and is associated with cognitive and mood phenotypes.
Authors: Collier MEW; Division of Genetics and Genome Biology, University of Leicester, University Road, Leicester, LE1 7RH, UK., Ceeney G; School of Chemistry, University of Leicester, University Road, Leicester, LE1 7RH, UK; Leicester Institute for Structural & Chemical Biology, Henry Wellcome Building, Lancaster Road, LE1 7HB., Chiappelli J; Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland, USA., Korrapati S; Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland, USA., Cao TH; Division of Cardiovascular Sciences, School of Medical Sciences, College of Life Sciences, University of Leicester, Leicester, LE1 7RH, United Kingdom.; National Institute for Health and Care Research Leicester Biomedical Research Centre, University Hospitals of Leicester NHS Trust, Glenfield Hospital, Leicester, LE3 9QP, United Kingdom.; Leicester van Geest Multi-OMICS facility, University of Leicester, Leicester, LE1 7RH, UK.; British Heart Foundation Centre of Research Excellence, College of Life Sciences, University of Leicester, Leicester, LE1 7RH, United Kingdom., Quinn P; Division of Cardiovascular Sciences, School of Medical Sciences, College of Life Sciences, University of Leicester, Leicester, LE1 7RH, United Kingdom.; Leicester van Geest Multi-OMICS facility, University of Leicester, Leicester, LE1 7RH, UK., Ma J; Manchester Institute of Biotechnology, University of Manchester, Princess Street, Manchester, M1 7DN, UK., Shauriq A; Division of Genetics and Genome Biology, University of Leicester, University Road, Leicester, LE1 7RH, UK., Sylvius N; Genomics Core Facility, University of Leicester, Leicester, UK., Hollox EJ; Division of Genetics and Genome Biology, University of Leicester, University Road, Leicester, LE1 7RH, UK., Jones DJL; Leicester van Geest Multi-OMICS facility, University of Leicester, Leicester, LE1 7RH, UK.; Leicester Cancer Research Centre, University Hospitals of Leicester NHS Trust, Leicester Royal Infirmary, University of Leicester, Leicester, LE1 5WW, United Kingdom., Hudson A; School of Chemistry, University of Leicester, University Road, Leicester, LE1 7RH, UK; Leicester Institute for Structural & Chemical Biology, Henry Wellcome Building, Lancaster Road, LE1 7HB., Hong EL; Department of Psychiatry and Behavioural Sciences, McGovern Medical School, University of Texas Health Science Center, Houston, Texas, USA., Scrutton N; Manchester Institute of Biotechnology, University of Manchester, Princess Street, Manchester, M1 7DN, UK., Schwarcz R; Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland, USA., Giorgini F; Division of Genetics and Genome Biology, University of Leicester, University Road, Leicester, LE1 7RH, UK.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 May 21. Date of Electronic Publication: 2026 May 21.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2692-8205
DOI:10.64898/2026.05.19.726163