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The single nucleotide polymorphism rs1053230 modulates kynurenine 3-monooxygenase stability and is associated with cognitive and mood phenotypes.

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Title: The single nucleotide polymorphism rs1053230 modulates kynurenine 3-monooxygenase stability and is associated with cognitive and mood phenotypes.
Authors: Collier MEW; Division of Genetics and Genome Biology, University of Leicester, University Road, Leicester, LE1 7RH, UK., Ceeney G; School of Chemistry, University of Leicester, University Road, Leicester, LE1 7RH, UK; Leicester Institute for Structural & Chemical Biology, Henry Wellcome Building, Lancaster Road, LE1 7HB., Chiappelli J; Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland, USA., Korrapati S; Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland, USA., Cao TH; Division of Cardiovascular Sciences, School of Medical Sciences, College of Life Sciences, University of Leicester, Leicester, LE1 7RH, United Kingdom.; National Institute for Health and Care Research Leicester Biomedical Research Centre, University Hospitals of Leicester NHS Trust, Glenfield Hospital, Leicester, LE3 9QP, United Kingdom.; Leicester van Geest Multi-OMICS facility, University of Leicester, Leicester, LE1 7RH, UK.; British Heart Foundation Centre of Research Excellence, College of Life Sciences, University of Leicester, Leicester, LE1 7RH, United Kingdom., Quinn P; Division of Cardiovascular Sciences, School of Medical Sciences, College of Life Sciences, University of Leicester, Leicester, LE1 7RH, United Kingdom.; Leicester van Geest Multi-OMICS facility, University of Leicester, Leicester, LE1 7RH, UK., Ma J; Manchester Institute of Biotechnology, University of Manchester, Princess Street, Manchester, M1 7DN, UK., Shauriq A; Division of Genetics and Genome Biology, University of Leicester, University Road, Leicester, LE1 7RH, UK., Sylvius N; Genomics Core Facility, University of Leicester, Leicester, UK., Hollox EJ; Division of Genetics and Genome Biology, University of Leicester, University Road, Leicester, LE1 7RH, UK., Jones DJL; Leicester van Geest Multi-OMICS facility, University of Leicester, Leicester, LE1 7RH, UK.; Leicester Cancer Research Centre, University Hospitals of Leicester NHS Trust, Leicester Royal Infirmary, University of Leicester, Leicester, LE1 5WW, United Kingdom., Hudson A; School of Chemistry, University of Leicester, University Road, Leicester, LE1 7RH, UK; Leicester Institute for Structural & Chemical Biology, Henry Wellcome Building, Lancaster Road, LE1 7HB., Hong EL; Department of Psychiatry and Behavioural Sciences, McGovern Medical School, University of Texas Health Science Center, Houston, Texas, USA., Scrutton N; Manchester Institute of Biotechnology, University of Manchester, Princess Street, Manchester, M1 7DN, UK., Schwarcz R; Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland, USA., Giorgini F; Division of Genetics and Genome Biology, University of Leicester, University Road, Leicester, LE1 7RH, UK.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 May 21. Date of Electronic Publication: 2026 May 21.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: The single nucleotide polymorphism rs1053230 modulates kynurenine 3-monooxygenase stability and is associated with cognitive and mood phenotypes.
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  Data: <searchLink fieldCode="AU" term="%22Collier+MEW%22">Collier MEW</searchLink>; Division of Genetics and Genome Biology, University of Leicester, University Road, Leicester, LE1 7RH, UK.<br /><searchLink fieldCode="AU" term="%22Ceeney+G%22">Ceeney G</searchLink>; School of Chemistry, University of Leicester, University Road, Leicester, LE1 7RH, UK; Leicester Institute for Structural & Chemical Biology, Henry Wellcome Building, Lancaster Road, LE1 7HB.<br /><searchLink fieldCode="AU" term="%22Chiappelli+J%22">Chiappelli J</searchLink>; Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Korrapati+S%22">Korrapati S</searchLink>; Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Cao+TH%22">Cao TH</searchLink>; Division of Cardiovascular Sciences, School of Medical Sciences, College of Life Sciences, University of Leicester, Leicester, LE1 7RH, United Kingdom.; National Institute for Health and Care Research Leicester Biomedical Research Centre, University Hospitals of Leicester NHS Trust, Glenfield Hospital, Leicester, LE3 9QP, United Kingdom.; Leicester van Geest Multi-OMICS facility, University of Leicester, Leicester, LE1 7RH, UK.; British Heart Foundation Centre of Research Excellence, College of Life Sciences, University of Leicester, Leicester, LE1 7RH, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Quinn+P%22">Quinn P</searchLink>; Division of Cardiovascular Sciences, School of Medical Sciences, College of Life Sciences, University of Leicester, Leicester, LE1 7RH, United Kingdom.; Leicester van Geest Multi-OMICS facility, University of Leicester, Leicester, LE1 7RH, UK.<br /><searchLink fieldCode="AU" term="%22Ma+J%22">Ma J</searchLink>; Manchester Institute of Biotechnology, University of Manchester, Princess Street, Manchester, M1 7DN, UK.<br /><searchLink fieldCode="AU" term="%22Shauriq+A%22">Shauriq A</searchLink>; Division of Genetics and Genome Biology, University of Leicester, University Road, Leicester, LE1 7RH, UK.<br /><searchLink fieldCode="AU" term="%22Sylvius+N%22">Sylvius N</searchLink>; Genomics Core Facility, University of Leicester, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Hollox+EJ%22">Hollox EJ</searchLink>; Division of Genetics and Genome Biology, University of Leicester, University Road, Leicester, LE1 7RH, UK.<br /><searchLink fieldCode="AU" term="%22Jones+DJL%22">Jones DJL</searchLink>; Leicester van Geest Multi-OMICS facility, University of Leicester, Leicester, LE1 7RH, UK.; Leicester Cancer Research Centre, University Hospitals of Leicester NHS Trust, Leicester Royal Infirmary, University of Leicester, Leicester, LE1 5WW, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Hudson+A%22">Hudson A</searchLink>; School of Chemistry, University of Leicester, University Road, Leicester, LE1 7RH, UK; Leicester Institute for Structural & Chemical Biology, Henry Wellcome Building, Lancaster Road, LE1 7HB.<br /><searchLink fieldCode="AU" term="%22Hong+EL%22">Hong EL</searchLink>; Department of Psychiatry and Behavioural Sciences, McGovern Medical School, University of Texas Health Science Center, Houston, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Scrutton+N%22">Scrutton N</searchLink>; Manchester Institute of Biotechnology, University of Manchester, Princess Street, Manchester, M1 7DN, UK.<br /><searchLink fieldCode="AU" term="%22Schwarcz+R%22">Schwarcz R</searchLink>; Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Giorgini+F%22">Giorgini F</searchLink>; Division of Genetics and Genome Biology, University of Leicester, University Road, Leicester, LE1 7RH, UK.
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