A generalizable system for antigenic peptide targeting across HLA-I allotypes.

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Title: A generalizable system for antigenic peptide targeting across HLA-I allotypes.
Authors: Blackson W; Department of Chemical Engineering, Stanford University, Stanford, CA, USA., Small EL; Center for Computational and Genomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Sun SM; Center for Computational and Genomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Cancer Biology Graduate Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Shinde O; Center for Computational and Genomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Pantula R; Center for Computational and Genomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Wang SJ; Department of Chemistry, Stanford University, Stanford, CA, USA., Rotsides P; Center for Computational and Genomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Du H; Department of Chemistry, Stanford University, Stanford, CA, USA., Sun Y; Center for Computational and Genomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Hwang D; Center for Computational and Genomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Wang CS; Center for Computational and Genomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Immunology Graduate Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Lu T; Department of Bioengineering, Stanford University, Stanford, CA, USA., Laskawy E; Center for Computational and Genomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Kapoor R; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Want MY; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., June CH; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.; Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, PA, USA.; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA., Young RM; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA.; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA., Maris JM; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Huang PS; Department of Chemistry, Stanford University, Stanford, CA, USA., Sgourakis NG; Center for Computational and Genomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Bioengineering, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 May 22. Date of Electronic Publication: 2026 May 22.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2692-8205
DOI:10.64898/2026.05.21.726655