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A generalizable system for antigenic peptide targeting across HLA-I allotypes.

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Title: A generalizable system for antigenic peptide targeting across HLA-I allotypes.
Authors: Blackson W; Department of Chemical Engineering, Stanford University, Stanford, CA, USA., Small EL; Center for Computational and Genomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Sun SM; Center for Computational and Genomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Cancer Biology Graduate Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Shinde O; Center for Computational and Genomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Pantula R; Center for Computational and Genomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Wang SJ; Department of Chemistry, Stanford University, Stanford, CA, USA., Rotsides P; Center for Computational and Genomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Du H; Department of Chemistry, Stanford University, Stanford, CA, USA., Sun Y; Center for Computational and Genomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Hwang D; Center for Computational and Genomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Wang CS; Center for Computational and Genomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Immunology Graduate Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Lu T; Department of Bioengineering, Stanford University, Stanford, CA, USA., Laskawy E; Center for Computational and Genomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Kapoor R; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Want MY; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., June CH; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.; Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, PA, USA.; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA., Young RM; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA.; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA., Maris JM; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Huang PS; Department of Chemistry, Stanford University, Stanford, CA, USA., Sgourakis NG; Center for Computational and Genomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Bioengineering, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 May 22. Date of Electronic Publication: 2026 May 22.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: A generalizable system for antigenic peptide targeting across HLA-I allotypes.
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  Data: <searchLink fieldCode="AU" term="%22Blackson+W%22">Blackson W</searchLink>; Department of Chemical Engineering, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Small+EL%22">Small EL</searchLink>; Center for Computational and Genomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Sun+SM%22">Sun SM</searchLink>; Center for Computational and Genomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Cancer Biology Graduate Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Shinde+O%22">Shinde O</searchLink>; Center for Computational and Genomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Pantula+R%22">Pantula R</searchLink>; Center for Computational and Genomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+SJ%22">Wang SJ</searchLink>; Department of Chemistry, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Rotsides+P%22">Rotsides P</searchLink>; Center for Computational and Genomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Du+H%22">Du H</searchLink>; Department of Chemistry, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Sun+Y%22">Sun Y</searchLink>; Center for Computational and Genomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Hwang+D%22">Hwang D</searchLink>; Center for Computational and Genomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+CS%22">Wang CS</searchLink>; Center for Computational and Genomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Immunology Graduate Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Lu+T%22">Lu T</searchLink>; Department of Bioengineering, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Laskawy+E%22">Laskawy E</searchLink>; Center for Computational and Genomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Kapoor+R%22">Kapoor R</searchLink>; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Want+MY%22">Want MY</searchLink>; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22June+CH%22">June CH</searchLink>; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA.; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.; Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, PA, USA.; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Young+RM%22">Young RM</searchLink>; Center for Cellular Immunotherapies of the University of Pennsylvania, Philadelphia, PA, USA.; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Maris+JM%22">Maris JM</searchLink>; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Huang+PS%22">Huang PS</searchLink>; Department of Chemistry, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Sgourakis+NG%22">Sgourakis NG</searchLink>; Center for Computational and Genomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Department of Bioengineering, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
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