Cell-type- and state-resolved transcriptomics uncovers distinct T cell and monocyte dysregulation in multiple sclerosis.

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Title: Cell-type- and state-resolved transcriptomics uncovers distinct T cell and monocyte dysregulation in multiple sclerosis.
Authors: Roostaei T; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA; Center for Translational and Computational Neuroimmunology, Division of Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA., Fujita M; Center for Translational and Computational Neuroimmunology, Division of Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA., Touil H; Center for Translational and Computational Neuroimmunology, Division of Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA., Kivisäkk P; Alzheimer's Clinical and Translational Research Unit, Department of Neurology, Massachusetts General Hospital, Boston, MA, USA., McCabe C; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Nejad P; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Sabrin A; Center for Translational and Computational Neuroimmunology, Division of Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA., Garcia FG; Center for Translational and Computational Neuroimmunology, Division of Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA., van Dorp CH; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Felsky D; Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, ON, Canada; Department of Psychiatry and Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada., Vlachos IS; Systems Biology and Computer Science Program, Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA., Hui D; Systems Biology and Computer Science Program, Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA., Fransson J; Sorbonne Université, Institut du Cerveau-Paris Brain Institute (ICM), INSERM, CNRS, APHP, Hôpital Pitié Salpétrière University Hospital, DMU Neuroscience 6, Paris, France., Macnair W; Roche Pharma Research and Early Development, Neuroscience and Rare Diseases, Roche Innovation Center, Basel, Switzerland., Williams A; Centre for Regenerative Medicine, Institute for Regeneration and Repair, MS Society Edinburgh Centre for MS Research, The University of Edinburgh, Edinburgh, UK., Zhang L; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA., Zhu W; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA., Xia Z; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA., Zujovic V; Sorbonne Université, Institut du Cerveau-Paris Brain Institute (ICM), INSERM, CNRS, APHP, Hôpital Pitié Salpétrière University Hospital, DMU Neuroscience 6, Paris, France., Patsopoulos NA; Systems Biology and Computer Science Program, Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA., Yates AJ; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Kuchroo VK; Evergrande Center for Immunologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Chitnis T; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Weiner HL; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Klein HU; Center for Translational and Computational Neuroimmunology, Division of Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA., De Jager PL; Center for Translational and Computational Neuroimmunology, Division of Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA; Multiple Sclerosis Center, Division of Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA. Electronic address: pld2115@cumc.columbia.edu.
Source: Cell reports [Cell Rep] 2026 Jun 23; Vol. 45 (6), pp. 117417. Date of Electronic Publication: 2026 Jun 06.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2211-1247
DOI:10.1016/j.celrep.2026.117417