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Cell-type- and state-resolved transcriptomics uncovers distinct T cell and monocyte dysregulation in multiple sclerosis.

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Title: Cell-type- and state-resolved transcriptomics uncovers distinct T cell and monocyte dysregulation in multiple sclerosis.
Authors: Roostaei T; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA; Center for Translational and Computational Neuroimmunology, Division of Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA., Fujita M; Center for Translational and Computational Neuroimmunology, Division of Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA., Touil H; Center for Translational and Computational Neuroimmunology, Division of Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA., Kivisäkk P; Alzheimer's Clinical and Translational Research Unit, Department of Neurology, Massachusetts General Hospital, Boston, MA, USA., McCabe C; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Nejad P; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Sabrin A; Center for Translational and Computational Neuroimmunology, Division of Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA., Garcia FG; Center for Translational and Computational Neuroimmunology, Division of Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA., van Dorp CH; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Felsky D; Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, ON, Canada; Department of Psychiatry and Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada., Vlachos IS; Systems Biology and Computer Science Program, Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA., Hui D; Systems Biology and Computer Science Program, Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA., Fransson J; Sorbonne Université, Institut du Cerveau-Paris Brain Institute (ICM), INSERM, CNRS, APHP, Hôpital Pitié Salpétrière University Hospital, DMU Neuroscience 6, Paris, France., Macnair W; Roche Pharma Research and Early Development, Neuroscience and Rare Diseases, Roche Innovation Center, Basel, Switzerland., Williams A; Centre for Regenerative Medicine, Institute for Regeneration and Repair, MS Society Edinburgh Centre for MS Research, The University of Edinburgh, Edinburgh, UK., Zhang L; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA., Zhu W; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA., Xia Z; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA., Zujovic V; Sorbonne Université, Institut du Cerveau-Paris Brain Institute (ICM), INSERM, CNRS, APHP, Hôpital Pitié Salpétrière University Hospital, DMU Neuroscience 6, Paris, France., Patsopoulos NA; Systems Biology and Computer Science Program, Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA., Yates AJ; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Kuchroo VK; Evergrande Center for Immunologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Chitnis T; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Weiner HL; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Klein HU; Center for Translational and Computational Neuroimmunology, Division of Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA., De Jager PL; Center for Translational and Computational Neuroimmunology, Division of Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA; Multiple Sclerosis Center, Division of Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA. Electronic address: pld2115@cumc.columbia.edu.
Source: Cell reports [Cell Rep] 2026 Jun 23; Vol. 45 (6), pp. 117417. Date of Electronic Publication: 2026 Jun 06.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Cell-type- and state-resolved transcriptomics uncovers distinct T cell and monocyte dysregulation in multiple sclerosis.
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  Data: <searchLink fieldCode="AU" term="%22Roostaei+T%22">Roostaei T</searchLink>; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA; Center for Translational and Computational Neuroimmunology, Division of Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Fujita+M%22">Fujita M</searchLink>; Center for Translational and Computational Neuroimmunology, Division of Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Touil+H%22">Touil H</searchLink>; Center for Translational and Computational Neuroimmunology, Division of Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Kivisäkk+P%22">Kivisäkk P</searchLink>; Alzheimer's Clinical and Translational Research Unit, Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22McCabe+C%22">McCabe C</searchLink>; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Nejad+P%22">Nejad P</searchLink>; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Sabrin+A%22">Sabrin A</searchLink>; Center for Translational and Computational Neuroimmunology, Division of Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Garcia+FG%22">Garcia FG</searchLink>; Center for Translational and Computational Neuroimmunology, Division of Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22van+Dorp+CH%22">van Dorp CH</searchLink>; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Felsky+D%22">Felsky D</searchLink>; Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, ON, Canada; Department of Psychiatry and Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Vlachos+IS%22">Vlachos IS</searchLink>; Systems Biology and Computer Science Program, Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Hui+D%22">Hui D</searchLink>; Systems Biology and Computer Science Program, Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Fransson+J%22">Fransson J</searchLink>; Sorbonne Université, Institut du Cerveau-Paris Brain Institute (ICM), INSERM, CNRS, APHP, Hôpital Pitié Salpétrière University Hospital, DMU Neuroscience 6, Paris, France.<br /><searchLink fieldCode="AU" term="%22Macnair+W%22">Macnair W</searchLink>; Roche Pharma Research and Early Development, Neuroscience and Rare Diseases, Roche Innovation Center, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Williams+A%22">Williams A</searchLink>; Centre for Regenerative Medicine, Institute for Regeneration and Repair, MS Society Edinburgh Centre for MS Research, The University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink>; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Zhu+W%22">Zhu W</searchLink>; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Xia+Z%22">Xia Z</searchLink>; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Zujovic+V%22">Zujovic V</searchLink>; Sorbonne Université, Institut du Cerveau-Paris Brain Institute (ICM), INSERM, CNRS, APHP, Hôpital Pitié Salpétrière University Hospital, DMU Neuroscience 6, Paris, France.<br /><searchLink fieldCode="AU" term="%22Patsopoulos+NA%22">Patsopoulos NA</searchLink>; Systems Biology and Computer Science Program, Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Yates+AJ%22">Yates AJ</searchLink>; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Kuchroo+VK%22">Kuchroo VK</searchLink>; Evergrande Center for Immunologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Chitnis+T%22">Chitnis T</searchLink>; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Weiner+HL%22">Weiner HL</searchLink>; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Klein+HU%22">Klein HU</searchLink>; Center for Translational and Computational Neuroimmunology, Division of Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22De+Jager+PL%22">De Jager PL</searchLink>; Center for Translational and Computational Neuroimmunology, Division of Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA; Multiple Sclerosis Center, Division of Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA. Electronic address: pld2115@cumc.columbia.edu.
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  Data: <searchLink fieldCode="JN" term="%22101573691%22">Cell reports</searchLink> [Cell Rep] 2026 Jun 23; Vol. 45 (6), pp. 117417. <i>Date of Electronic Publication: </i>2026 Jun 06.
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