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Inhibition of soluble epoxide hydrolase ameliorates renal injury in IgA nephropathy by restoring epoxyeicosatrienoic acids.

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Title: Inhibition of soluble epoxide hydrolase ameliorates renal injury in IgA nephropathy by restoring epoxyeicosatrienoic acids.
Authors: Yin HH; CNTTI of College of Pharmacy & Anesthesia Department of the Second Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China.; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China., Fu X; CNTTI of College of Pharmacy & Anesthesia Department of the Second Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China.; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China., Qiao Q; The Department of Nephrology, the Fourth Affiliated Hospital of Soochow University, Suzhou 215125, China., Yang E; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China., Liu YN; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China., Bai Y; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China., Huang L; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China., Chen YY; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China., Huang ZY; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China., Yu DC; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China., Dai P; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China., Pan QJ; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China., Meng YW; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China., Yin SY; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China., Liu X; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China., Nie S; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China., Deng BQ; The Department of Nephrology, the Fourth Affiliated Hospital of Soochow University, Suzhou 215125, China., He Y; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China., Liu JY; CNTTI of College of Pharmacy & Anesthesia Department of the Second Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China.; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.
Source: IScience [iScience] 2026 Jun 01; Vol. 29 (6), pp. 116200. Date of Electronic Publication: 2026 Jun 01 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2589-0042
DOI:10.1016/j.isci.2026.116200