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Inhibition of soluble epoxide hydrolase ameliorates renal injury in IgA nephropathy by restoring epoxyeicosatrienoic acids.

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Title: Inhibition of soluble epoxide hydrolase ameliorates renal injury in IgA nephropathy by restoring epoxyeicosatrienoic acids.
Authors: Yin HH; CNTTI of College of Pharmacy & Anesthesia Department of the Second Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China.; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China., Fu X; CNTTI of College of Pharmacy & Anesthesia Department of the Second Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China.; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China., Qiao Q; The Department of Nephrology, the Fourth Affiliated Hospital of Soochow University, Suzhou 215125, China., Yang E; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China., Liu YN; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China., Bai Y; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China., Huang L; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China., Chen YY; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China., Huang ZY; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China., Yu DC; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China., Dai P; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China., Pan QJ; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China., Meng YW; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China., Yin SY; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China., Liu X; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China., Nie S; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China., Deng BQ; The Department of Nephrology, the Fourth Affiliated Hospital of Soochow University, Suzhou 215125, China., He Y; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China., Liu JY; CNTTI of College of Pharmacy & Anesthesia Department of the Second Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China.; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.
Source: IScience [iScience] 2026 Jun 01; Vol. 29 (6), pp. 116200. Date of Electronic Publication: 2026 Jun 01 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Inhibition of soluble epoxide hydrolase ameliorates renal injury in IgA nephropathy by restoring epoxyeicosatrienoic acids.
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  Data: <searchLink fieldCode="AU" term="%22Yin+HH%22">Yin HH</searchLink>; CNTTI of College of Pharmacy & Anesthesia Department of the Second Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China.; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.<br /><searchLink fieldCode="AU" term="%22Fu+X%22">Fu X</searchLink>; CNTTI of College of Pharmacy & Anesthesia Department of the Second Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China.; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.<br /><searchLink fieldCode="AU" term="%22Qiao+Q%22">Qiao Q</searchLink>; The Department of Nephrology, the Fourth Affiliated Hospital of Soochow University, Suzhou 215125, China.<br /><searchLink fieldCode="AU" term="%22Yang+E%22">Yang E</searchLink>; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.<br /><searchLink fieldCode="AU" term="%22Liu+YN%22">Liu YN</searchLink>; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.<br /><searchLink fieldCode="AU" term="%22Bai+Y%22">Bai Y</searchLink>; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.<br /><searchLink fieldCode="AU" term="%22Huang+L%22">Huang L</searchLink>; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.<br /><searchLink fieldCode="AU" term="%22Chen+YY%22">Chen YY</searchLink>; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.<br /><searchLink fieldCode="AU" term="%22Huang+ZY%22">Huang ZY</searchLink>; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.<br /><searchLink fieldCode="AU" term="%22Yu+DC%22">Yu DC</searchLink>; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.<br /><searchLink fieldCode="AU" term="%22Dai+P%22">Dai P</searchLink>; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.<br /><searchLink fieldCode="AU" term="%22Pan+QJ%22">Pan QJ</searchLink>; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.<br /><searchLink fieldCode="AU" term="%22Meng+YW%22">Meng YW</searchLink>; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.<br /><searchLink fieldCode="AU" term="%22Yin+SY%22">Yin SY</searchLink>; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.<br /><searchLink fieldCode="AU" term="%22Nie+S%22">Nie S</searchLink>; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.<br /><searchLink fieldCode="AU" term="%22Deng+BQ%22">Deng BQ</searchLink>; The Department of Nephrology, the Fourth Affiliated Hospital of Soochow University, Suzhou 215125, China.<br /><searchLink fieldCode="AU" term="%22He+Y%22">He Y</searchLink>; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.<br /><searchLink fieldCode="AU" term="%22Liu+JY%22">Liu JY</searchLink>; CNTTI of College of Pharmacy & Anesthesia Department of the Second Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China.; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (CNTTI), Ministry of Education, Chongqing 400016, China.; Department of Chemical Biology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.
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  Data: <searchLink fieldCode="JN" term="%22101724038%22">IScience</searchLink> [iScience] 2026 Jun 01; Vol. 29 (6), pp. 116200. <i>Date of Electronic Publication: </i>2026 Jun 01 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101724038 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>2589-0042 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2225890042%22">25890042 </searchLink><i>NLM ISO Abbreviation: </i>iScience <i>Subsets: </i>PubMed not MEDLINE
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