Efficacy and safety of toripalimab in combination with cetuximab in patients with recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC): a phase 1b/2 study.
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| Title: | Efficacy and safety of toripalimab in combination with cetuximab in patients with recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC): a phase 1b/2 study. |
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| Authors: | Guo Y; Department of Oncology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China. pattrickguo@gmail.com., Li Z; Department of Head and Neck Surgery, Liaoning Cancer Hospital & Institute, Shenyang, China., Xue L; Department of Oncology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China., Lin J; Department of Comprehensive Chemotherapy/Daytime Chemotherapy, Hunan Cancer Hospital, Changsha, China., Qu S; Department of Radiation Oncology, Guangxi Medical University Cancer Hospital, Nanning, China., Sun C; Department of Head and Neck Surgery Section II, Yunnan Cancer Hospital, Third Affiliated Hospital of Kunming Medical University, Kunming, China., Fang M; Department of Rare Cancer & Head and Neck Medical Oncology, Zhejiang Cancer Hospital, Hangzhou, China., Zhu Y; Department of Otolaryngology-Head and Neck Surgery, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Zong J; Department of Radiation Oncology, Fujian Medical University Cancer Hospital, Fuzhou, China., Chen W; Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Cao G; Department of Medical Oncology, Jiangsu Cancer Hospital, Nanjing, China., Wu J; Department of Head and Neck Genitourinary Medicine, Harbin Medical University Cancer Hospital, Harbin, China., Ge M; Department of Head and Neck Surgery, Zhejiang Provincial People's Hospital, Hangzhou, China., Li Z; Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China., Wang S; Department of Head and Neck Oncology, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China., Wang X; Department of Maxillofacial and Otorhinolaryngological Oncology, Tianjin Medical University Cancer Institute & Hospital, Tianjin, China., Jiang H; Department of Radiation Oncology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, China., Hu D; Department of Radiotherapy, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Shen L; Department of Oncology, Xiangya Hospital, Central South University, Changsha, China., Wei Y; Department of Head and Neck Radiotherapy, Shandong Provincial ENT Hospital, Shandong University, Jinan, China., Jin C; Department of Medical Oncology, Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou, China., Zhang H; Department of Head & Neck Oncology, West China Hospital, Sichuan University, Chengdu, China., Huang X; Department of Otorhinolaryngology-Head and Neck Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China., Sun Y; Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing, China., Shi J; Department of Oncology, Linyi Cancer Hospital, Linyi, China., Wang M; Shanghai Junshi Biosciences, Shanghai, China., Luo X; Shanghai Junshi Biosciences, Shanghai, China., Kuang S; Shanghai Junshi Biosciences, Shanghai, China., Wei S; Shanghai Junshi Biosciences, Shanghai, China., Deng R; Shanghai Junshi Biosciences, Shanghai, China., Shen Y; Shanghai Junshi Biosciences, Shanghai, China. |
| Source: | Signal transduction and targeted therapy [Signal Transduct Target Ther] 2026 Jun 09; Vol. 11 (1). Date of Electronic Publication: 2026 Jun 09. |
| Publication Type: | Journal Article; Clinical Trial, Phase I; Multicenter Study; Clinical Trial, Phase II |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2059-3635 |
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| DOI: | 10.1038/s41392-026-02707-3 |
