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Efficacy and safety of toripalimab in combination with cetuximab in patients with recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC): a phase 1b/2 study.

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Title: Efficacy and safety of toripalimab in combination with cetuximab in patients with recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC): a phase 1b/2 study.
Authors: Guo Y; Department of Oncology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China. pattrickguo@gmail.com., Li Z; Department of Head and Neck Surgery, Liaoning Cancer Hospital & Institute, Shenyang, China., Xue L; Department of Oncology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China., Lin J; Department of Comprehensive Chemotherapy/Daytime Chemotherapy, Hunan Cancer Hospital, Changsha, China., Qu S; Department of Radiation Oncology, Guangxi Medical University Cancer Hospital, Nanning, China., Sun C; Department of Head and Neck Surgery Section II, Yunnan Cancer Hospital, Third Affiliated Hospital of Kunming Medical University, Kunming, China., Fang M; Department of Rare Cancer & Head and Neck Medical Oncology, Zhejiang Cancer Hospital, Hangzhou, China., Zhu Y; Department of Otolaryngology-Head and Neck Surgery, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Zong J; Department of Radiation Oncology, Fujian Medical University Cancer Hospital, Fuzhou, China., Chen W; Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Cao G; Department of Medical Oncology, Jiangsu Cancer Hospital, Nanjing, China., Wu J; Department of Head and Neck Genitourinary Medicine, Harbin Medical University Cancer Hospital, Harbin, China., Ge M; Department of Head and Neck Surgery, Zhejiang Provincial People's Hospital, Hangzhou, China., Li Z; Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China., Wang S; Department of Head and Neck Oncology, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China., Wang X; Department of Maxillofacial and Otorhinolaryngological Oncology, Tianjin Medical University Cancer Institute & Hospital, Tianjin, China., Jiang H; Department of Radiation Oncology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, China., Hu D; Department of Radiotherapy, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Shen L; Department of Oncology, Xiangya Hospital, Central South University, Changsha, China., Wei Y; Department of Head and Neck Radiotherapy, Shandong Provincial ENT Hospital, Shandong University, Jinan, China., Jin C; Department of Medical Oncology, Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou, China., Zhang H; Department of Head & Neck Oncology, West China Hospital, Sichuan University, Chengdu, China., Huang X; Department of Otorhinolaryngology-Head and Neck Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China., Sun Y; Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing, China., Shi J; Department of Oncology, Linyi Cancer Hospital, Linyi, China., Wang M; Shanghai Junshi Biosciences, Shanghai, China., Luo X; Shanghai Junshi Biosciences, Shanghai, China., Kuang S; Shanghai Junshi Biosciences, Shanghai, China., Wei S; Shanghai Junshi Biosciences, Shanghai, China., Deng R; Shanghai Junshi Biosciences, Shanghai, China., Shen Y; Shanghai Junshi Biosciences, Shanghai, China.
Source: Signal transduction and targeted therapy [Signal Transduct Target Ther] 2026 Jun 09; Vol. 11 (1). Date of Electronic Publication: 2026 Jun 09.
Publication Type: Journal Article; Clinical Trial, Phase I; Multicenter Study; Clinical Trial, Phase II
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Efficacy and safety of toripalimab in combination with cetuximab in patients with recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC): a phase 1b/2 study.
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  Data: <searchLink fieldCode="AU" term="%22Guo+Y%22">Guo Y</searchLink>; Department of Oncology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China. pattrickguo@gmail.com.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Department of Head and Neck Surgery, Liaoning Cancer Hospital & Institute, Shenyang, China.<br /><searchLink fieldCode="AU" term="%22Xue+L%22">Xue L</searchLink>; Department of Oncology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Lin+J%22">Lin J</searchLink>; Department of Comprehensive Chemotherapy/Daytime Chemotherapy, Hunan Cancer Hospital, Changsha, China.<br /><searchLink fieldCode="AU" term="%22Qu+S%22">Qu S</searchLink>; Department of Radiation Oncology, Guangxi Medical University Cancer Hospital, Nanning, China.<br /><searchLink fieldCode="AU" term="%22Sun+C%22">Sun C</searchLink>; Department of Head and Neck Surgery Section II, Yunnan Cancer Hospital, Third Affiliated Hospital of Kunming Medical University, Kunming, China.<br /><searchLink fieldCode="AU" term="%22Fang+M%22">Fang M</searchLink>; Department of Rare Cancer & Head and Neck Medical Oncology, Zhejiang Cancer Hospital, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhu+Y%22">Zhu Y</searchLink>; Department of Otolaryngology-Head and Neck Surgery, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Zong+J%22">Zong J</searchLink>; Department of Radiation Oncology, Fujian Medical University Cancer Hospital, Fuzhou, China.<br /><searchLink fieldCode="AU" term="%22Chen+W%22">Chen W</searchLink>; Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Cao+G%22">Cao G</searchLink>; Department of Medical Oncology, Jiangsu Cancer Hospital, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Wu+J%22">Wu J</searchLink>; Department of Head and Neck Genitourinary Medicine, Harbin Medical University Cancer Hospital, Harbin, China.<br /><searchLink fieldCode="AU" term="%22Ge+M%22">Ge M</searchLink>; Department of Head and Neck Surgery, Zhejiang Provincial People's Hospital, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Wang+S%22">Wang S</searchLink>; Department of Head and Neck Oncology, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Department of Maxillofacial and Otorhinolaryngological Oncology, Tianjin Medical University Cancer Institute & Hospital, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Jiang+H%22">Jiang H</searchLink>; Department of Radiation Oncology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, China.<br /><searchLink fieldCode="AU" term="%22Hu+D%22">Hu D</searchLink>; Department of Radiotherapy, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Shen+L%22">Shen L</searchLink>; Department of Oncology, Xiangya Hospital, Central South University, Changsha, China.<br /><searchLink fieldCode="AU" term="%22Wei+Y%22">Wei Y</searchLink>; Department of Head and Neck Radiotherapy, Shandong Provincial ENT Hospital, Shandong University, Jinan, China.<br /><searchLink fieldCode="AU" term="%22Jin+C%22">Jin C</searchLink>; Department of Medical Oncology, Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhang+H%22">Zhang H</searchLink>; Department of Head & Neck Oncology, West China Hospital, Sichuan University, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Huang+X%22">Huang X</searchLink>; Department of Otorhinolaryngology-Head and Neck Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Sun+Y%22">Sun Y</searchLink>; Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Shi+J%22">Shi J</searchLink>; Department of Oncology, Linyi Cancer Hospital, Linyi, China.<br /><searchLink fieldCode="AU" term="%22Wang+M%22">Wang M</searchLink>; Shanghai Junshi Biosciences, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Luo+X%22">Luo X</searchLink>; Shanghai Junshi Biosciences, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Kuang+S%22">Kuang S</searchLink>; Shanghai Junshi Biosciences, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Wei+S%22">Wei S</searchLink>; Shanghai Junshi Biosciences, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Deng+R%22">Deng R</searchLink>; Shanghai Junshi Biosciences, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Shen+Y%22">Shen Y</searchLink>; Shanghai Junshi Biosciences, Shanghai, China.
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  Data: <searchLink fieldCode="JN" term="%22101676423%22">Signal transduction and targeted therapy</searchLink> [Signal Transduct Target Ther] 2026 Jun 09; Vol. 11 (1). <i>Date of Electronic Publication: </i>2026 Jun 09.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101676423 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2059-3635 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220593635%22">20593635 </searchLink><i>NLM ISO Abbreviation: </i>Signal Transduct Target Ther <i>Subsets: </i>MEDLINE
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