Thiadiazole-4β-sulfur-demethylepipodophyllotoxin traps human topoisomerase IIβ by distorting DNA and disrupting the tyrosyl-DNA linkage.

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Title: Thiadiazole-4β-sulfur-demethylepipodophyllotoxin traps human topoisomerase IIβ by distorting DNA and disrupting the tyrosyl-DNA linkage.
Authors: Ali MS; State Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, China., Zhao W; State Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, China; Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan, 430068, China., Li HM; Human Phenome Institute, Fudan University, Shanghai, 201210, China., Cong JY; State Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, China. Electronic address: congjy@email.sdu.edu.cn., Tang YJ; State Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, China; State Key Laboratory of Genetics and Development of Complex Phenotypes, College of Biotechnology, Fudan University, Shanghai, 200433, China. Electronic address: yajietang@fudan.edu.cn.
Source: International journal of biological macromolecules [Int J Biol Macromol] 2026 Jul; Vol. 370, pp. 152972. Date of Electronic Publication: 2026 Jun 08.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE; In Process
Database: MEDLINE Ultimate
Description
ISSN:1879-0003
DOI:10.1016/j.ijbiomac.2026.152972