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Thiadiazole-4β-sulfur-demethylepipodophyllotoxin traps human topoisomerase IIβ by distorting DNA and disrupting the tyrosyl-DNA linkage.

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Title: Thiadiazole-4β-sulfur-demethylepipodophyllotoxin traps human topoisomerase IIβ by distorting DNA and disrupting the tyrosyl-DNA linkage.
Authors: Ali MS; State Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, China., Zhao W; State Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, China; Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan, 430068, China., Li HM; Human Phenome Institute, Fudan University, Shanghai, 201210, China., Cong JY; State Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, China. Electronic address: congjy@email.sdu.edu.cn., Tang YJ; State Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, China; State Key Laboratory of Genetics and Development of Complex Phenotypes, College of Biotechnology, Fudan University, Shanghai, 200433, China. Electronic address: yajietang@fudan.edu.cn.
Source: International journal of biological macromolecules [Int J Biol Macromol] 2026 Jul; Vol. 370, pp. 152972. Date of Electronic Publication: 2026 Jun 08.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Thiadiazole-4β-sulfur-demethylepipodophyllotoxin traps human topoisomerase IIβ by distorting DNA and disrupting the tyrosyl-DNA linkage.
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  Data: <searchLink fieldCode="AU" term="%22Ali+MS%22">Ali MS</searchLink>; State Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, China.<br /><searchLink fieldCode="AU" term="%22Zhao+W%22">Zhao W</searchLink>; State Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, China; Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan, 430068, China.<br /><searchLink fieldCode="AU" term="%22Li+HM%22">Li HM</searchLink>; Human Phenome Institute, Fudan University, Shanghai, 201210, China.<br /><searchLink fieldCode="AU" term="%22Cong+JY%22">Cong JY</searchLink>; State Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, China. Electronic address: congjy@email.sdu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Tang+YJ%22">Tang YJ</searchLink>; State Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, China; State Key Laboratory of Genetics and Development of Complex Phenotypes, College of Biotechnology, Fudan University, Shanghai, 200433, China. Electronic address: yajietang@fudan.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%227909578%22">International journal of biological macromolecules</searchLink> [Int J Biol Macromol] 2026 Jul; Vol. 370, pp. 152972. <i>Date of Electronic Publication: </i>2026 Jun 08.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>7909578 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1879-0003 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201418130%22">01418130 </searchLink><i>NLM ISO Abbreviation: </i>Int J Biol Macromol <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.ijbiomac.2026.152972
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      – Code: eng
        Text: English
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      – TitleFull: Thiadiazole-4β-sulfur-demethylepipodophyllotoxin traps human topoisomerase IIβ by distorting DNA and disrupting the tyrosyl-DNA linkage.
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            NameFull: Ali MS
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            NameFull: Zhao W
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            NameFull: Li HM
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            – D: 01
              M: 07
              Text: 2026 Jul
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              Y: 2026
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              Value: 370
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            – TitleFull: International journal of biological macromolecules
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