Genomic landscape of drug binding and pharmacogenetic variation across diverse populations using SNPdrug3D.

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Title: Genomic landscape of drug binding and pharmacogenetic variation across diverse populations using SNPdrug3D.
Authors: Malik AJ; Atomistic Simulations and Design in Biology, Bioinformatics Institute, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.; Australian Centre for Ecogenomics, The University of Queensland, Brisbane, QLD, Australia.; Computational Biology and Clinical Informatics, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia., Kenanov D; Protein Sequence Analysis, Bioinformatics Institute, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Chong CS; Protein Sequence Analysis, Bioinformatics Institute, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Ozturk MB; Experimental Drug Development Centre, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Wang Q; Department of Chemistry, Southern University of Science and Technology, Shenzhen, China., Chang HY; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Hebrard M; NPM-Genomic Intelligence & Informatics Engine (NPM-GINIE), Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Precision Health Research Singapore (PRECISE), Singapore, Singapore.; Garvan Institute of Medical Research, Sydney, NSW, Australia., Ho YS; Bioprocessing Technology Institute, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Wang Z; Duke-NUS Medical School, Singapore, Singapore., Limviphuvadh V; Protein Sequence Analysis, Bioinformatics Institute, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Miyajima JMT; Protein Sequence Analysis, Bioinformatics Institute, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Kannan S; Atomistic Simulations and Design in Biology, Bioinformatics Institute, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Magallanes RT; NPM-Genomic Intelligence & Informatics Engine (NPM-GINIE), Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Sim X; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore., Chai JF; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore., Davila S; Duke-NUS Medical School, Singapore, Singapore.; SingHealth Duke-NUS Institute of Precision Medicine, Singapore, Singapore.; SingHealth Duke-NUS Genomic Medicine Centre, Singapore, Singapore., Yeo KK; Duke-NUS Medical School, Singapore, Singapore.; SingHealth Duke-NUS Institute of Precision Medicine, Singapore, Singapore.; Department of Cardiology, National Heart Centre Singapore, Singapore, Singapore., Leong KP; Centre for Precision and Genomic Medicine, Tan Tock Seng Hospital, Singapore, Singapore., Goh LL; Centre for Precision and Genomic Medicine, Tan Tock Seng Hospital, Singapore, Singapore., Karnani N; Institute for Human Development and Potential, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Clinical Data Engagement, Bioinformatics Institute, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Department of Biochemistry, National University of Singapore, Singapore, Singapore., Eriksson JG; Institute for Human Development and Potential, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.; Folkhalsan Research Center, Helsinki, Finland.; Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland., Cheng CY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Centre for Innovation and Precision Eye Health, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore., Wong TY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Beijing Visual Science and Translational Eye Research Institute (BERI), Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing, China., Loh M; Population and Global Health, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Laboratory of DNA Methylation and Population Epigenetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Dalan R; Department of Endocrinology, Tan Tock Seng Hospital, Singapore, Singapore., Khor CC; Laboratory of Complex Disease Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Chew GL; Illumina Singapore, Singapore, Singapore., Lim WK; SingHealth Duke-NUS Institute of Precision Medicine, Singapore, Singapore.; Cancer & Stem Cell Biology Program, Duke-NUS Medical School, Singapore, Singapore.; Laboratory of Genome Variation Analytics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Ngeow J; Population and Global Health, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.; Cancer Genetics Service, Division of Medical Oncology, National Cancer Centre, Singapore, Singapore.; Oncology Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore., Chambers JC; Precision Health Research Singapore (PRECISE), Singapore, Singapore.; Population and Global Health, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.; Department of Epidemiology and Biostatistics, Imperial College London, London, UK., Tai ES; Precision Health Research Singapore (PRECISE), Singapore, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore., Bertin N; NPM-Genomic Intelligence & Informatics Engine (NPM-GINIE), Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Tan CSH; Department of Chemistry, Southern University of Science and Technology, Shenzhen, China., Koh J; Experimental Drug Development Centre, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Department of Biomedical Informatics, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore., Tan P; Precision Health Research Singapore (PRECISE), Singapore, Singapore.; Duke-NUS Medical School, Singapore, Singapore.; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Verma CS; Atomistic Simulations and Design in Biology, Bioinformatics Institute, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore. chandra@a-star.edu.sg.; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore. chandra@a-star.edu.sg.; Department of Biological Sciences, National University of Singapore, Singapore, Singapore. chandra@a-star.edu.sg., Maurer-Stroh S; Protein Sequence Analysis, Bioinformatics Institute, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore. sebastianms@a-star.edu.sg.; Department of Biological Sciences, National University of Singapore, Singapore, Singapore. sebastianms@a-star.edu.sg.; Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore. sebastianms@a-star.edu.sg.
Corporate Authors: SG10K_Health Consortium
Source: Nature communications [Nat Commun] 2026 Jun 09. Date of Electronic Publication: 2026 Jun 09.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-026-73816-4