Loss of PDL1 in mesenchymal stromal cells from young-onset MDS-RAEB-1 promotes inflamm-aging through epigenetic dysregulation of H3K9me3.

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Title: Loss of PDL1 in mesenchymal stromal cells from young-onset MDS-RAEB-1 promotes inflamm-aging through epigenetic dysregulation of H3K9me3.
Authors: Lv P; Department of Clinical Laboratory, Zhengzhou Central Hospital Affiliated Zhengzhou University, Zhengzhou, China., Jin R; Department of Clinical Laboratory, Zhengzhou Central Hospital Affiliated Zhengzhou University, Zhengzhou, China., Sun L; Department of Clinical Laboratory, Zhengzhou Central Hospital Affiliated Zhengzhou University, Zhengzhou, China., Li Y; Stem Cell Research Center, Henan Provincial People's Hospital, Zhengzhou, Henan, China.; Henan Key Laboratory of Stem Cell Clinical Application and Key Technology, Henan Provincial People's Hospital, Zhengzhou, China., Cheng C; Stem Cell Research Center, Henan Provincial People's Hospital, Zhengzhou, Henan, China.; Henan Key Laboratory of Stem Cell Clinical Application and Key Technology, Henan Provincial People's Hospital, Zhengzhou, China., Shi L; Department of Hematology, Zhengzhou Central Hospital Affiliated Zhengzhou University, Zhengzhou, China., Shen S; Department of Thoracic Surgery, Henan Cancer Hospital, Zhengzhou, China., Wang H; MOE Key Laboratory of Protein Science, School of Medicine, Tsinghua University, Beijing, China., Yue H; Stem Cell Research Center, Henan Provincial People's Hospital, Zhengzhou, Henan, China.; Henan Key Laboratory of Stem Cell Clinical Application and Key Technology, Henan Provincial People's Hospital, Zhengzhou, China.
Source: Stem cells translational medicine [Stem Cells Transl Med] 2026 May 18; Vol. 15 (6).
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 101578022 Publication Model: Print Cited Medium: Internet ISSN: 2157-6580 (Electronic) Linking ISSN: 21576564 NLM ISO Abbreviation: Stem Cells Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2157-6580
DOI:10.1093/stcltm/szag025