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Histaminylation alters collagen matrix mechanics and attenuates cardiac fibrosis post-myocardial infarction via mechanotransduction signaling axis.

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Title: Histaminylation alters collagen matrix mechanics and attenuates cardiac fibrosis post-myocardial infarction via mechanotransduction signaling axis.
Authors: Zhu J; Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.; Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China.; NHC Key Laboratory of Ischemic Heart Diseases, State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China., Sun D; Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.; Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China.; NHC Key Laboratory of Ischemic Heart Diseases, State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China., Zeng G; Department of Cardiology, the Second Affiliated Hospital, Hengyang Medical School, Key Laboratory of Heart Failure Prevention & Treatment of Hengyang, Clinical Medicine Research Center of Arteriosclerotic Disease of Hunan Province, University of South China, Hengyang, China., Wu K; Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.; Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China.; NHC Key Laboratory of Ischemic Heart Diseases, State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China., Yang X; Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.; NHC Key Laboratory of Ischemic Heart Diseases, State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China., Zhu X; Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.; Department of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China., Aierken D; Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.; NHC Key Laboratory of Ischemic Heart Diseases, State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China., Ding S; Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.; NHC Key Laboratory of Ischemic Heart Diseases, State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China., Wang X; Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China. wang.xiangfei@zs-hospital.sh.cn.; Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China. wang.xiangfei@zs-hospital.sh.cn.; NHC Key Laboratory of Ischemic Heart Diseases, State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China. wang.xiangfei@zs-hospital.sh.cn., Ge J; Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China. jbge@zs-hospital.sh.cn.; Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China. jbge@zs-hospital.sh.cn.; NHC Key Laboratory of Ischemic Heart Diseases, State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China. jbge@zs-hospital.sh.cn., Yang X; Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China. yangxiangdong_zs@163.com.; Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China. yangxiangdong_zs@163.com.; NHC Key Laboratory of Ischemic Heart Diseases, State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China. yangxiangdong_zs@163.com.; Department of Cardiology, the Second Affiliated Hospital, Hengyang Medical School, Key Laboratory of Heart Failure Prevention & Treatment of Hengyang, Clinical Medicine Research Center of Arteriosclerotic Disease of Hunan Province, University of South China, Hengyang, China. yangxiangdong_zs@163.com.
Source: Signal transduction and targeted therapy [Signal Transduct Target Ther] 2026 Jun 11; Vol. 11 (1). Date of Electronic Publication: 2026 Jun 11.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Histaminylation alters collagen matrix mechanics and attenuates cardiac fibrosis post-myocardial infarction via mechanotransduction signaling axis.
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  Data: <searchLink fieldCode="AU" term="%22Zhu+J%22">Zhu J</searchLink>; Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.; Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China.; NHC Key Laboratory of Ischemic Heart Diseases, State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Sun+D%22">Sun D</searchLink>; Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.; Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China.; NHC Key Laboratory of Ischemic Heart Diseases, State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zeng+G%22">Zeng G</searchLink>; Department of Cardiology, the Second Affiliated Hospital, Hengyang Medical School, Key Laboratory of Heart Failure Prevention & Treatment of Hengyang, Clinical Medicine Research Center of Arteriosclerotic Disease of Hunan Province, University of South China, Hengyang, China.<br /><searchLink fieldCode="AU" term="%22Wu+K%22">Wu K</searchLink>; Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.; Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China.; NHC Key Laboratory of Ischemic Heart Diseases, State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Yang+X%22">Yang X</searchLink>; Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.; NHC Key Laboratory of Ischemic Heart Diseases, State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zhu+X%22">Zhu X</searchLink>; Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.; Department of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Aierken+D%22">Aierken D</searchLink>; Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.; NHC Key Laboratory of Ischemic Heart Diseases, State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Ding+S%22">Ding S</searchLink>; Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.; NHC Key Laboratory of Ischemic Heart Diseases, State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China. wang.xiangfei@zs-hospital.sh.cn.; Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China. wang.xiangfei@zs-hospital.sh.cn.; NHC Key Laboratory of Ischemic Heart Diseases, State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China. wang.xiangfei@zs-hospital.sh.cn.<br /><searchLink fieldCode="AU" term="%22Ge+J%22">Ge J</searchLink>; Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China. jbge@zs-hospital.sh.cn.; Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China. jbge@zs-hospital.sh.cn.; NHC Key Laboratory of Ischemic Heart Diseases, State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China. jbge@zs-hospital.sh.cn.<br /><searchLink fieldCode="AU" term="%22Yang+X%22">Yang X</searchLink>; Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China. yangxiangdong_zs@163.com.; Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China. yangxiangdong_zs@163.com.; NHC Key Laboratory of Ischemic Heart Diseases, State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China. yangxiangdong_zs@163.com.; Department of Cardiology, the Second Affiliated Hospital, Hengyang Medical School, Key Laboratory of Heart Failure Prevention & Treatment of Hengyang, Clinical Medicine Research Center of Arteriosclerotic Disease of Hunan Province, University of South China, Hengyang, China. yangxiangdong_zs@163.com.
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        Value: 10.1038/s41392-026-02721-5
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              Text: 2026 Jun 11
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