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Activation of c-Myc confers resistance to venetoclax via inhibition of Bim in t(8;21)-positive acute myeloid leukemia.

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Title: Activation of c-Myc confers resistance to venetoclax via inhibition of Bim in t(8;21)-positive acute myeloid leukemia.
Authors: Yin Z; Department of Hematology, Nanfang Hospital, Southern Medical University, No.1838, North of Guangzhou Avenue, Guangzhou City, Guangdong Province, 510515, China.; Clinical Medical Research Center of Hematological Diseases of Guangdong Province, Guangzhou, Guangdong Province, 510515, China., Yao Z; Department of Hematology, Nanfang Hospital, Southern Medical University, No.1838, North of Guangzhou Avenue, Guangzhou City, Guangdong Province, 510515, China.; Clinical Medical Research Center of Hematological Diseases of Guangdong Province, Guangzhou, Guangdong Province, 510515, China., Chen D; Department of Hematology, Nanfang Hospital, Southern Medical University, No.1838, North of Guangzhou Avenue, Guangzhou City, Guangdong Province, 510515, China.; Clinical Medical Research Center of Hematological Diseases of Guangdong Province, Guangzhou, Guangdong Province, 510515, China., Xu D; Department of Hematology, Nanfang Hospital, Southern Medical University, No.1838, North of Guangzhou Avenue, Guangzhou City, Guangdong Province, 510515, China.; Clinical Medical Research Center of Hematological Diseases of Guangdong Province, Guangzhou, Guangdong Province, 510515, China., Xuan L; Department of Hematology, Nanfang Hospital, Southern Medical University, No.1838, North of Guangzhou Avenue, Guangzhou City, Guangdong Province, 510515, China.; Clinical Medical Research Center of Hematological Diseases of Guangdong Province, Guangzhou, Guangdong Province, 510515, China., Liu Q; Department of Hematology, Nanfang Hospital, Southern Medical University, No.1838, North of Guangzhou Avenue, Guangzhou City, Guangdong Province, 510515, China.; Clinical Medical Research Center of Hematological Diseases of Guangdong Province, Guangzhou, Guangdong Province, 510515, China., Ping B; Department of Hematology, Huiqiao Medical Center, Nanfang Hospital, Southern Medical University, No.1838, North of Guangzhou Avenue, Guangzhou City, Guangdong Province, 510515, China. nfyypingbaohong66@163.com., Yu G; Department of Hematology, Nanfang Hospital, Southern Medical University, No.1838, North of Guangzhou Avenue, Guangzhou City, Guangdong Province, 510515, China. yugpp@163.com.; The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, Guangdong Province, 510317, China. yugpp@163.com.; Clinical Medical Research Center of Hematological Diseases of Guangdong Province, Guangzhou, Guangdong Province, 510515, China. yugpp@163.com.
Source: Cell communication and signaling : CCS [Cell Commun Signal] 2026 Jun 11. Date of Electronic Publication: 2026 Jun 11.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101170464 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-811X (Electronic) Linking ISSN: 1478811X NLM ISO Abbreviation: Cell Commun Signal Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1478-811X
DOI:10.1186/s12964-026-02994-x