Circulating sphingosine-1-phosphate depletion is associated with endothelial activation and altered brain-endothelial S1P pathway expression in ischemic stroke.

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Title: Circulating sphingosine-1-phosphate depletion is associated with endothelial activation and altered brain-endothelial S1P pathway expression in ischemic stroke.
Authors: Porschen LT; Department of Experimental Medical Science, Lund University, Lund, 221 84, Sweden.; Wallenberg Centre for Molecular Medicine, Lund University, Lund, 221 84, Sweden.; Division of Physiology & Vascular Biology, Institute of Theoretical Medicine, Faculty of Medicine, University of Augsburg, Universitätsstr. 2, 86159, Augsburg, Germany., Matthes F; Department of Experimental Medical Science, Lund University, Lund, 221 84, Sweden.; Wallenberg Centre for Molecular Medicine, Lund University, Lund, 221 84, Sweden.; Division of Physiology & Vascular Biology, Institute of Theoretical Medicine, Faculty of Medicine, University of Augsburg, Universitätsstr. 2, 86159, Augsburg, Germany., Matuskova H; Department of Experimental Medical Science, Lund University, Lund, 221 84, Sweden.; Wallenberg Centre for Molecular Medicine, Lund University, Lund, 221 84, Sweden.; Department of Vascular Neurology, University Hospital Bonn, 53127, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE), 53127, Bonn, Germany., Braadt L; Division of Physiology & Vascular Biology, Institute of Theoretical Medicine, Faculty of Medicine, University of Augsburg, Universitätsstr. 2, 86159, Augsburg, Germany.; Department of Neurology and Clinical Neurophysiology, University Hospital Augsburg, Augsburg, Germany., Petzold GC; Department of Vascular Neurology, University Hospital Bonn, 53127, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE), 53127, Bonn, Germany., Lindgren AG; Department of Clinical Sciences Lund, Neurology, Lund University, Lund, Sweden.; Department of Neurology, Rehabilitation Medicine, Memory Disorders and Geriatrics, Skåne University Hospital, Lund, Sweden., Meissner A; Department of Experimental Medical Science, Lund University, Lund, 221 84, Sweden. anja.meissner@uni-a.de.; Wallenberg Centre for Molecular Medicine, Lund University, Lund, 221 84, Sweden. anja.meissner@uni-a.de.; Division of Physiology & Vascular Biology, Institute of Theoretical Medicine, Faculty of Medicine, University of Augsburg, Universitätsstr. 2, 86159, Augsburg, Germany. anja.meissner@uni-a.de.
Source: Fluids and barriers of the CNS [Fluids Barriers CNS] 2026 Jun 12; Vol. 23 (1). Date of Electronic Publication: 2026 Jun 12.
Publication Type: Journal Article
Journal Info: Publisher: Biomed Central Country of Publication: England NLM ID: 101553157 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-8118 (Electronic) Linking ISSN: 20458118 NLM ISO Abbreviation: Fluids Barriers CNS Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2045-8118
DOI:10.1186/s12987-026-00828-z