Mutant KRAS-driven selective mRNA translation reveals mechanisms and therapeutic vulnerabilities in cancer.

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Bibliographic Details
Title: Mutant KRAS-driven selective mRNA translation reveals mechanisms and therapeutic vulnerabilities in cancer.
Authors: Shrivastava A; Department of Molecular Pharmacology, Stem Cell and Cancer Biology Program, Immunotherapy for Cancer and Inflammatory Disorders, Cancer Dormancy Institute, Data Science Institute, Albert Einstein College of Medicine, Montefiore Einstein Comprehensive Cancer Center, Bronx, NY 10461, USA., Pederson EN; Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts Amherst, Amherst, MA 01003, USA., Nguyen TU; Department of Molecular Pharmacology, Stem Cell and Cancer Biology Program, Immunotherapy for Cancer and Inflammatory Disorders, Cancer Dormancy Institute, Data Science Institute, Albert Einstein College of Medicine, Montefiore Einstein Comprehensive Cancer Center, Bronx, NY 10461, USA., Chuen J; Department of Molecular Pharmacology, Stem Cell and Cancer Biology Program, Immunotherapy for Cancer and Inflammatory Disorders, Cancer Dormancy Institute, Data Science Institute, Albert Einstein College of Medicine, Montefiore Einstein Comprehensive Cancer Center, Bronx, NY 10461, USA., Mohan P; Department of Molecular Pharmacology, Stem Cell and Cancer Biology Program, Immunotherapy for Cancer and Inflammatory Disorders, Cancer Dormancy Institute, Data Science Institute, Albert Einstein College of Medicine, Montefiore Einstein Comprehensive Cancer Center, Bronx, NY 10461, USA., Pande S; Department of Molecular Pharmacology, Stem Cell and Cancer Biology Program, Immunotherapy for Cancer and Inflammatory Disorders, Cancer Dormancy Institute, Data Science Institute, Albert Einstein College of Medicine, Montefiore Einstein Comprehensive Cancer Center, Bronx, NY 10461, USA., Toribio AR; Department of Molecular Pharmacology, Stem Cell and Cancer Biology Program, Immunotherapy for Cancer and Inflammatory Disorders, Cancer Dormancy Institute, Data Science Institute, Albert Einstein College of Medicine, Montefiore Einstein Comprehensive Cancer Center, Bronx, NY 10461, USA; University Francisco de Vitoria, 28223 Madrid, Spain., Lecomte N; David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA., Melchor J; David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA., McAuliffe JC; Department of Surgery and Pathology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY 10461, USA., Grandgenett PM; Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA., Rajasekhar VK; Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA., Nishikawa K; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Tri-Institutional PhD Program in Chemical Biology, New York, NY, USA., Knörlein A; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., David Y; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Tri-Institutional PhD Program in Chemical Biology, New York, NY, USA; Department of Physiology, Biophysics and Systems Biology, Weill Cornell Medicine, New York, NY, USA; Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA., Willis IM; Department of Biochemistry, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY 10461, USA., Iacobuzio-Donahue CA; David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA., Ouyang Z; Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts Amherst, Amherst, MA 01003, USA., Singh K; Department of Molecular Pharmacology, Stem Cell and Cancer Biology Program, Immunotherapy for Cancer and Inflammatory Disorders, Cancer Dormancy Institute, Data Science Institute, Albert Einstein College of Medicine, Montefiore Einstein Comprehensive Cancer Center, Bronx, NY 10461, USA. Electronic address: kamini.singh@einsteinmed.edu.
Source: Cell reports [Cell Rep] 2026 Jun 23; Vol. 45 (6), pp. 117520. Date of Electronic Publication: 2026 Jun 12.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2211-1247
DOI:10.1016/j.celrep.2026.117520