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Strengths and pitfalls of NNT and NNH in early breast cancer escalation trials.

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Title: Strengths and pitfalls of NNT and NNH in early breast cancer escalation trials.
Authors: Buonaiuto R; Clinical and Translational Oncology, Scuola Superiore Meridionale, Via Mezzocannone 4, Naples, 80134, Italy; Department of Breast and Thoracic Oncology, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', Via Mariano Semmola 52, Napoli, 80131, Italy; Université Libre de Bruxelles (ULB), Hôpital Universitaire de Bruxelles (H.U.B), Institut Jules Bordet, Bruxelles, Belgium., Mangiacotti FP; Oncology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Via Sergio Pansini 5, Naples, 80131, Italy., Giudici F; Unit of Cancer Epidemiology, CRO Aviano, National Cancer Institute, IRCCS, Via Franco Gallini 2, Aviano, 33081, Italy., Tafuro M; Clinical and Translational Oncology, Scuola Superiore Meridionale, Via Mezzocannone 4, Naples, 80134, Italy; Department of Breast and Thoracic Oncology, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', Via Mariano Semmola 52, Napoli, 80131, Italy., Scarfetta R; Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro Del Portillo 200, Roma, 00128, Italy., Longobardi A; Oncology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Via Sergio Pansini 5, Naples, 80131, Italy., Pagliuca M; Clinical and Translational Oncology, Scuola Superiore Meridionale, Via Mezzocannone 4, Naples, 80134, Italy; Molecular Predictors and New Targets in Oncology, Inserm U981, Université Paris-Saclay, Gustave Roussy, 114 Rue Edouard Vaillant, Villejuif, 94800, France., Caltavituro A; Clinical and Translational Oncology, Scuola Superiore Meridionale, Via Mezzocannone 4, Naples, 80134, Italy., Arecco L; Université Libre de Bruxelles (ULB), Hôpital Universitaire de Bruxelles (H.U.B), Institut Jules Bordet, Bruxelles, Belgium., de Azambuja E; Université Libre de Bruxelles (ULB), Hôpital Universitaire de Bruxelles (H.U.B), Institut Jules Bordet, Bruxelles, Belgium., Giuliano M; Oncology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Via Sergio Pansini 5, Naples, 80131, Italy., Arpino G; Oncology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Via Sergio Pansini 5, Naples, 80131, Italy., Del Mastro L; Department of Medical Oncology, IRCCS Ospedale Policlinico San Martino, Largo R. Benzi 10, Genova, 16132, Italy; Dipartimento di Medicina Interna e Specialità Mediche (DIMI), University of Genova, Viale Benedetto XV 6, Genova, 16132, Italy., De Angelis C; Clinical and Translational Oncology, Scuola Superiore Meridionale, Via Mezzocannone 4, Naples, 80134, Italy; Department of Breast and Thoracic Oncology, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', Via Mariano Semmola 52, Napoli, 80131, Italy., De Laurentiis M; Clinical and Translational Oncology, Scuola Superiore Meridionale, Via Mezzocannone 4, Naples, 80134, Italy; Department of Breast and Thoracic Oncology, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', Via Mariano Semmola 52, Napoli, 80131, Italy., Puglisi F; Department of Medical Oncology, CRO Aviano, National Cancer Institute, IRCCS, Via Franco Gallini 2, Aviano, 33081, Italy; Department of Medicine, University of Udine, Via Palladio 8, Udine, 33100, Italy. Electronic address: fabio.puglisi@uniud.it.
Source: Breast (Edinburgh, Scotland) [Breast] 2026 May 29; Vol. 88, pp. 104820. Date of Electronic Publication: 2026 May 29.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9213011 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-3080 (Electronic) Linking ISSN: 09609776 NLM ISO Abbreviation: Breast Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Strengths and pitfalls of NNT and NNH in early breast cancer escalation trials.
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  Data: <searchLink fieldCode="AU" term="%22Buonaiuto+R%22">Buonaiuto R</searchLink>; Clinical and Translational Oncology, Scuola Superiore Meridionale, Via Mezzocannone 4, Naples, 80134, Italy; Department of Breast and Thoracic Oncology, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', Via Mariano Semmola 52, Napoli, 80131, Italy; Université Libre de Bruxelles (ULB), Hôpital Universitaire de Bruxelles (H.U.B), Institut Jules Bordet, Bruxelles, Belgium.<br /><searchLink fieldCode="AU" term="%22Mangiacotti+FP%22">Mangiacotti FP</searchLink>; Oncology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Via Sergio Pansini 5, Naples, 80131, Italy.<br /><searchLink fieldCode="AU" term="%22Giudici+F%22">Giudici F</searchLink>; Unit of Cancer Epidemiology, CRO Aviano, National Cancer Institute, IRCCS, Via Franco Gallini 2, Aviano, 33081, Italy.<br /><searchLink fieldCode="AU" term="%22Tafuro+M%22">Tafuro M</searchLink>; Clinical and Translational Oncology, Scuola Superiore Meridionale, Via Mezzocannone 4, Naples, 80134, Italy; Department of Breast and Thoracic Oncology, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', Via Mariano Semmola 52, Napoli, 80131, Italy.<br /><searchLink fieldCode="AU" term="%22Scarfetta+R%22">Scarfetta R</searchLink>; Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro Del Portillo 200, Roma, 00128, Italy.<br /><searchLink fieldCode="AU" term="%22Longobardi+A%22">Longobardi A</searchLink>; Oncology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Via Sergio Pansini 5, Naples, 80131, Italy.<br /><searchLink fieldCode="AU" term="%22Pagliuca+M%22">Pagliuca M</searchLink>; Clinical and Translational Oncology, Scuola Superiore Meridionale, Via Mezzocannone 4, Naples, 80134, Italy; Molecular Predictors and New Targets in Oncology, Inserm U981, Université Paris-Saclay, Gustave Roussy, 114 Rue Edouard Vaillant, Villejuif, 94800, France.<br /><searchLink fieldCode="AU" term="%22Caltavituro+A%22">Caltavituro A</searchLink>; Clinical and Translational Oncology, Scuola Superiore Meridionale, Via Mezzocannone 4, Naples, 80134, Italy.<br /><searchLink fieldCode="AU" term="%22Arecco+L%22">Arecco L</searchLink>; Université Libre de Bruxelles (ULB), Hôpital Universitaire de Bruxelles (H.U.B), Institut Jules Bordet, Bruxelles, Belgium.<br /><searchLink fieldCode="AU" term="%22de+Azambuja+E%22">de Azambuja E</searchLink>; Université Libre de Bruxelles (ULB), Hôpital Universitaire de Bruxelles (H.U.B), Institut Jules Bordet, Bruxelles, Belgium.<br /><searchLink fieldCode="AU" term="%22Giuliano+M%22">Giuliano M</searchLink>; Oncology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Via Sergio Pansini 5, Naples, 80131, Italy.<br /><searchLink fieldCode="AU" term="%22Arpino+G%22">Arpino G</searchLink>; Oncology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Via Sergio Pansini 5, Naples, 80131, Italy.<br /><searchLink fieldCode="AU" term="%22Del+Mastro+L%22">Del Mastro L</searchLink>; Department of Medical Oncology, IRCCS Ospedale Policlinico San Martino, Largo R. Benzi 10, Genova, 16132, Italy; Dipartimento di Medicina Interna e Specialità Mediche (DIMI), University of Genova, Viale Benedetto XV 6, Genova, 16132, Italy.<br /><searchLink fieldCode="AU" term="%22De+Angelis+C%22">De Angelis C</searchLink>; Clinical and Translational Oncology, Scuola Superiore Meridionale, Via Mezzocannone 4, Naples, 80134, Italy; Department of Breast and Thoracic Oncology, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', Via Mariano Semmola 52, Napoli, 80131, Italy.<br /><searchLink fieldCode="AU" term="%22De+Laurentiis+M%22">De Laurentiis M</searchLink>; Clinical and Translational Oncology, Scuola Superiore Meridionale, Via Mezzocannone 4, Naples, 80134, Italy; Department of Breast and Thoracic Oncology, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', Via Mariano Semmola 52, Napoli, 80131, Italy.<br /><searchLink fieldCode="AU" term="%22Puglisi+F%22">Puglisi F</searchLink>; Department of Medical Oncology, CRO Aviano, National Cancer Institute, IRCCS, Via Franco Gallini 2, Aviano, 33081, Italy; Department of Medicine, University of Udine, Via Palladio 8, Udine, 33100, Italy. Electronic address: fabio.puglisi@uniud.it.
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  Data: <searchLink fieldCode="JN" term="%229213011%22">Breast (Edinburgh, Scotland)</searchLink> [Breast] 2026 May 29; Vol. 88, pp. 104820. <i>Date of Electronic Publication: </i>2026 May 29.
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