A progeria syndrome links DNA hypermethylation to age-related pathology.

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Bibliographic Details
Title: A progeria syndrome links DNA hypermethylation to age-related pathology.
Authors: Sarni D; MRC Human Genetics Unit, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK., Neary G; MRC Human Genetics Unit, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK.; Easter Bush Pathology, The Royal (Dick) School of Veterinary Studies and the Roslin Institute, The University of Edinburgh, Edinburgh, UK., Carroll PL; MRC Human Genetics Unit, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK., Vink CS; Centre for Inflammation Research, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, UK., Billard CV; CRUK Scotland Centre, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK., Isobe T; Cambridge Stem Cell Institute, University of Cambridge, Jeffrey Cheah Biomedical Centre, Cambridge, UK., Weng X; MRC Human Genetics Unit, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK.; Institute for Neuroscience and Cardiovascular Research, The University of Edinburgh, Edinburgh, UK., Portman JR; Centre for Inflammation Research, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, UK., McCartney DL; Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK., Heyn P; MRC Human Genetics Unit, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK., van 't Hof RJ; Vanthof Scientific, Rozgarty, Poland., Morrison LR; Easter Bush Pathology, The Royal (Dick) School of Veterinary Studies and the Roslin Institute, The University of Edinburgh, Edinburgh, UK., Martin CA; MRC Human Genetics Unit, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK., Stok C; MRC Human Genetics Unit, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK., Harley ME; MRC Human Genetics Unit, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK., Leitch A; MRC Human Genetics Unit, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK., van den Ancker M; MRC Human Genetics Unit, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK., Robertson N; MRC Human Genetics Unit, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK., Kitto L; Centre for Inflammation Research, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, UK., Clark R; Edinburgh Clinical Research Facility, The University of Edinburgh, Edinburgh, UK., Rennie M; Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK., Popravko A; Centre for Inflammation Research, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, UK., McClure JJ; Rheumatology Research Group, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK., Parry DA; MRC Human Genetics Unit, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK., Camiolo G; Centre for Regenerative Medicine, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, UK., Leah T; Centre for Regenerative Medicine, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, UK., Jakobczyk H; Centre for Regenerative Medicine, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, UK., Megaw R; MRC Human Genetics Unit, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK.; Princess Alexandra Eye Pavilion, NHS Lothian, Edinburgh, UK., McKie L; MRC Human Genetics Unit, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK., Marshall GF; Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK.; Simons Initiative for the Developing Brain, The University of Edinburgh, Edinburgh, UK., Balkic N; Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK.; Simons Initiative for the Developing Brain, The University of Edinburgh, Edinburgh, UK., Amiel J; Service de Médecine Génomique des Maladies Rares, Hôpital Necker-Enfants Malades, Assistance Publique des Hôpitaux de Paris (AP-HP), Paris, France., Barragán Arévalo T; Human Genetics Department, National Institute of Pediatrics, Mexico City, Mexico., Bronken McCarthy G; Genetic Counselling, M Health Fairview, Minneapolis, MN, USA., Buchanan CA; Dell Children's Medical Group, Dell Medical School, Austin, TX, USA., Buffet A; Université Paris Cité, Inserm, PARCC, Équipe Labellisée Ligue contre le Cancer, Paris, France.; Assistance Publique-Hôpitaux de Paris (AP-HP) Centre, Hôpital Européen Georges Pompidou, Département de Médecine Génomique des Tumeurs et des Cancers, Fédération de Génétique et de Médecine Génomique, Paris, France., Cascón A; Hereditary Endocrine Cancer Group, Spanish National Cancer Research Centre (CNIO), Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Madrid, Spain., Cogne B; Nantes Université, CHU de Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.; Nantes Université, CHU de Nantes, Service de Génétique Médicale, Nantes, France., Conrad S; Nantes Université, CHU de Nantes, Service de Génétique Médicale, Nantes, France., Cueto-González AM; Àrea de Genètica Clínica i Molecular (HUVH), Medicine Genetics Research Group (VHIR), Mòdul de Consultes de Genètica Clínica i Malalties Minoritàries, Hospital Universitari Vall d'Hebron, Barcelona, Spain., Currás-Freixes M; Familial Cancer Clinical Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Houge GD; Department of Medical Genetics, Haukeland University Hospital, Bergen, Norway., Fong CT; Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA., George-Abraham JK; Dell Children's Medical Group, Dell Medical School, Austin, TX, USA., Gibson K; Genetic Health Service New Zealand, Christchurch Hospital, Christchurch, New Zealand., Ibáñez L; Department of Endocrinology, Pediatric Research Institute Sant Joan de Déu, University of Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), ISCIII, Madrid, Spain., Longo N; Division of Clinical Genetics, Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA., Lussey-Lepoutre C; Sorbonne University, Nuclear Medicine Department, Pitié-Salpêtrière Hospital, Assistance Publique Hôpitaux de Paris, Centre de recherche des Cordeliers, Université Paris-Cité, Sorbonne Université, Inserm, U1138, Equipe Labellisée Ligue contre le Cancer, Paris, France., Miller BS; Pediatric Endocrinology, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA., Moles-Fernandez A; Àrea de Genètica Clínica i Molecular (HUVH), Medicine Genetics Research Group (VHIR), Mòdul de Consultes de Genètica Clínica i Malalties Minoritàries, Hospital Universitari Vall d'Hebron, Barcelona, Spain., Pillai NR; Division of Genetics and Metabolism, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA., Tvrdik T; Department of Pathology, University of Utah, Salt Lake City, UT, USA.; ARUP Laboratories, Salt Lake City, UT, USA.; Caris Life Sciences, Phoenix, AZ, USA., Vincent M; Nantes Université, CHU de Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.; Nantes Université, CHU de Nantes, Service de Génétique Médicale, Nantes, France., Yokoyama E; Human Genetics Department, National Institute of Pediatrics, Mexico City, Mexico., Abbott CM; Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK.; Simons Initiative for the Developing Brain, The University of Edinburgh, Edinburgh, UK., Sanchez-Luque FJ; Institute of Parasitology and Biomedicine 'Lopez-Neyra', Spanish National Research Council, Granada, Spain., Ottersbach K; Centre for Regenerative Medicine, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, UK., De Bari C; Rheumatology Research Group, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK., Roelofs AJ; Rheumatology Research Group, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK., Tillotson R; Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK., Kranc KR; Institute of Cancer Research, London, UK.; Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK., Brown SJ; Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK., Marioni RE; Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK., Crisan M; Centre for Regenerative Medicine, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, UK., Göttgens B; Cambridge Stem Cell Institute, University of Cambridge, Jeffrey Cheah Biomedical Centre, Cambridge, UK., Henderson NC; MRC Human Genetics Unit, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK.; Centre for Inflammation Research, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, UK., Semple RK; MRC Human Genetics Unit, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK.; Institute for Neuroscience and Cardiovascular Research, The University of Edinburgh, Edinburgh, UK., Myant KB; CRUK Scotland Centre, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK., Dzierzak E; Centre for Inflammation Research, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, UK., Reijns MAM; MRC Human Genetics Unit, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK., Sproul D; Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK., Jackson AP; MRC Human Genetics Unit, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK. andrew.jackson@ed.ac.uk.
Source: Nature genetics [Nat Genet] 2026 Jun 12. Date of Electronic Publication: 2026 Jun 12.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1546-1718
DOI:10.1038/s41588-026-02633-8