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Anti-CD4 monoclonal antibody treatment enhances CD8+ T cell antitumor immunity and suppresses tumor growth in pulmonary fibrosis-associated lung cancer in mice.

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Title: Anti-CD4 monoclonal antibody treatment enhances CD8+ T cell antitumor immunity and suppresses tumor growth in pulmonary fibrosis-associated lung cancer in mice.
Authors: Nishioka T; Department of Immunology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan., Sakabe T; Department of Immunology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan., Kitabatake M; Department of Immunology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan., Ouji-Sageshima N; Department of Immunology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan., Hara A; Department of Immunology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan., Sato I; Department of Respiratory Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan., Fujioka N; Department of Respiratory Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan., Furukawa R; Department of Immunology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan., Kasamatsu-Nishimura T; Department of Immunology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan., Hontsu S; Department of Respiratory Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan., Muro S; Department of Respiratory Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan., Ito T; Department of Immunology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan. toshi-ito@naramed-u.ac.jp.
Source: Scientific reports [Sci Rep] 2026 Jun 12. Date of Electronic Publication: 2026 Jun 12.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2045-2322
DOI:10.1038/s41598-026-57394-5