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Anti-CD4 monoclonal antibody treatment enhances CD8+ T cell antitumor immunity and suppresses tumor growth in pulmonary fibrosis-associated lung cancer in mice.

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Title: Anti-CD4 monoclonal antibody treatment enhances CD8+ T cell antitumor immunity and suppresses tumor growth in pulmonary fibrosis-associated lung cancer in mice.
Authors: Nishioka T; Department of Immunology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan., Sakabe T; Department of Immunology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan., Kitabatake M; Department of Immunology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan., Ouji-Sageshima N; Department of Immunology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan., Hara A; Department of Immunology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan., Sato I; Department of Respiratory Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan., Fujioka N; Department of Respiratory Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan., Furukawa R; Department of Immunology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan., Kasamatsu-Nishimura T; Department of Immunology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan., Hontsu S; Department of Respiratory Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan., Muro S; Department of Respiratory Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan., Ito T; Department of Immunology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan. toshi-ito@naramed-u.ac.jp.
Source: Scientific reports [Sci Rep] 2026 Jun 12. Date of Electronic Publication: 2026 Jun 12.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Anti-CD4 monoclonal antibody treatment enhances CD8<superscript>+</superscript> T cell antitumor immunity and suppresses tumor growth in pulmonary fibrosis-associated lung cancer in mice.
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  Data: <searchLink fieldCode="AU" term="%22Nishioka+T%22">Nishioka T</searchLink>; Department of Immunology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan.<br /><searchLink fieldCode="AU" term="%22Sakabe+T%22">Sakabe T</searchLink>; Department of Immunology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan.<br /><searchLink fieldCode="AU" term="%22Kitabatake+M%22">Kitabatake M</searchLink>; Department of Immunology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan.<br /><searchLink fieldCode="AU" term="%22Ouji-Sageshima+N%22">Ouji-Sageshima N</searchLink>; Department of Immunology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan.<br /><searchLink fieldCode="AU" term="%22Hara+A%22">Hara A</searchLink>; Department of Immunology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan.<br /><searchLink fieldCode="AU" term="%22Sato+I%22">Sato I</searchLink>; Department of Respiratory Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.<br /><searchLink fieldCode="AU" term="%22Fujioka+N%22">Fujioka N</searchLink>; Department of Respiratory Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.<br /><searchLink fieldCode="AU" term="%22Furukawa+R%22">Furukawa R</searchLink>; Department of Immunology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan.<br /><searchLink fieldCode="AU" term="%22Kasamatsu-Nishimura+T%22">Kasamatsu-Nishimura T</searchLink>; Department of Immunology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan.<br /><searchLink fieldCode="AU" term="%22Hontsu+S%22">Hontsu S</searchLink>; Department of Respiratory Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.<br /><searchLink fieldCode="AU" term="%22Muro+S%22">Muro S</searchLink>; Department of Respiratory Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.<br /><searchLink fieldCode="AU" term="%22Ito+T%22">Ito T</searchLink>; Department of Immunology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan. toshi-ito@naramed-u.ac.jp.
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  Data: <searchLink fieldCode="JN" term="%22101563288%22">Scientific reports</searchLink> [Sci Rep] 2026 Jun 12. <i>Date of Electronic Publication: </i>2026 Jun 12.
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              Text: 2026 Jun 12
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