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Anchusa azurea enhances cisplatin efficacy in oral and bone cancers through IL-17 and TNF-α pathway modulation: a metabolomic and network pharmacology approach.

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Title: Anchusa azurea enhances cisplatin efficacy in oral and bone cancers through IL-17 and TNF-α pathway modulation: a metabolomic and network pharmacology approach.
Authors: Fahim SA; Department of Biochemistry, School of Pharmacy, Newgiza University (NGU), Newgiza, km 22 Cairo-Alexandria Desert Road, Giza, 12577, Egypt. sallyatef@hotmail.com., El-Haddad AE; Department of Pharmacognosy, Faculty of Pharmacy, October 6 University, Giza, 12585, Egypt., Moustafa RI; Microbial Biotechnology Department, Biotechnology Research Institute , National Research Centre, Dokki, P.O. Box 12622, Cairo, Egypt.; Department of Microbiology, School of Pharmacy, Newgiza University (NGU), , Newgiza, km 22 Cairo-Alexandria Desert Road, Giza, 12577, Egypt., Ali SO; Department of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt., Sharaky M; Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt., El Sherazy NH; Department of Clinical Pharmacy, School of Pharmacy, Newgiza University (NGU), Km 22 Cairo-Alexandria Desert Road, P.O. Box 12577, Newgiza, Giza, Egypt.; Department of Clinical pharmacy, Cairo University Hospitals, Cairo university, Cairo, Egypt., Elsherbiny AA; Department of Biochemistry, School of Pharmacy, Newgiza University (NGU), Newgiza, km 22 Cairo-Alexandria Desert Road, Giza, 12577, Egypt., Nabawy AY; Microbial Biotechnology Department, Biotechnology Research Institute , National Research Centre, Dokki, P.O. Box 12622, Cairo, Egypt., Elwakil AA; School of Pharmacy, Newgiza University (NGU), Newgiza, km 22 Cairo- Alexandria Desert Road, Giza, 12577, Egypt., Esam HA; School of Pharmacy, Newgiza University (NGU), Newgiza, km 22 Cairo- Alexandria Desert Road, Giza, 12577, Egypt., Emad S; School of Pharmacy, Newgiza University (NGU), Newgiza, km 22 Cairo- Alexandria Desert Road, Giza, 12577, Egypt., Abdelrahman M; School of Pharmacy, Newgiza University (NGU), Newgiza, km 22 Cairo- Alexandria Desert Road, Giza, 12577, Egypt., Ayman M; School of Pharmacy, Newgiza University (NGU), Newgiza, km 22 Cairo- Alexandria Desert Road, Giza, 12577, Egypt., Soliman HAH; School of Pharmacy, Newgiza University (NGU), Newgiza, km 22 Cairo- Alexandria Desert Road, Giza, 12577, Egypt., El-Deeb EM; Pharmacognosy Department, Faculty of Pharmacy and drug technology, Egyptian Chinese University, Cairo, 11771, Egypt., Saadeldeen AM; Department of Pharmacognosy, School of Pharmacy, Newgiza University (NGU), Newgiza, km 22 Cairo-Alexandria Desert Road, Giza, 12577, Egypt.
Source: Scientific reports [Sci Rep] 2026 Jun 13; Vol. 16 (1). Date of Electronic Publication: 2026 Jun 13.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Anchusa azurea enhances cisplatin efficacy in oral and bone cancers through IL-17 and TNF-α pathway modulation: a metabolomic and network pharmacology approach.
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  Data: <searchLink fieldCode="AU" term="%22Fahim+SA%22">Fahim SA</searchLink>; Department of Biochemistry, School of Pharmacy, Newgiza University (NGU), Newgiza, km 22 Cairo-Alexandria Desert Road, Giza, 12577, Egypt. sallyatef@hotmail.com.<br /><searchLink fieldCode="AU" term="%22El-Haddad+AE%22">El-Haddad AE</searchLink>; Department of Pharmacognosy, Faculty of Pharmacy, October 6 University, Giza, 12585, Egypt.<br /><searchLink fieldCode="AU" term="%22Moustafa+RI%22">Moustafa RI</searchLink>; Microbial Biotechnology Department, Biotechnology Research Institute , National Research Centre, Dokki, P.O. Box 12622, Cairo, Egypt.; Department of Microbiology, School of Pharmacy, Newgiza University (NGU), , Newgiza, km 22 Cairo-Alexandria Desert Road, Giza, 12577, Egypt.<br /><searchLink fieldCode="AU" term="%22Ali+SO%22">Ali SO</searchLink>; Department of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt.<br /><searchLink fieldCode="AU" term="%22Sharaky+M%22">Sharaky M</searchLink>; Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22El+Sherazy+NH%22">El Sherazy NH</searchLink>; Department of Clinical Pharmacy, School of Pharmacy, Newgiza University (NGU), Km 22 Cairo-Alexandria Desert Road, P.O. Box 12577, Newgiza, Giza, Egypt.; Department of Clinical pharmacy, Cairo University Hospitals, Cairo university, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Elsherbiny+AA%22">Elsherbiny AA</searchLink>; Department of Biochemistry, School of Pharmacy, Newgiza University (NGU), Newgiza, km 22 Cairo-Alexandria Desert Road, Giza, 12577, Egypt.<br /><searchLink fieldCode="AU" term="%22Nabawy+AY%22">Nabawy AY</searchLink>; Microbial Biotechnology Department, Biotechnology Research Institute , National Research Centre, Dokki, P.O. Box 12622, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Elwakil+AA%22">Elwakil AA</searchLink>; School of Pharmacy, Newgiza University (NGU), Newgiza, km 22 Cairo- Alexandria Desert Road, Giza, 12577, Egypt.<br /><searchLink fieldCode="AU" term="%22Esam+HA%22">Esam HA</searchLink>; School of Pharmacy, Newgiza University (NGU), Newgiza, km 22 Cairo- Alexandria Desert Road, Giza, 12577, Egypt.<br /><searchLink fieldCode="AU" term="%22Emad+S%22">Emad S</searchLink>; School of Pharmacy, Newgiza University (NGU), Newgiza, km 22 Cairo- Alexandria Desert Road, Giza, 12577, Egypt.<br /><searchLink fieldCode="AU" term="%22Abdelrahman+M%22">Abdelrahman M</searchLink>; School of Pharmacy, Newgiza University (NGU), Newgiza, km 22 Cairo- Alexandria Desert Road, Giza, 12577, Egypt.<br /><searchLink fieldCode="AU" term="%22Ayman+M%22">Ayman M</searchLink>; School of Pharmacy, Newgiza University (NGU), Newgiza, km 22 Cairo- Alexandria Desert Road, Giza, 12577, Egypt.<br /><searchLink fieldCode="AU" term="%22Soliman+HAH%22">Soliman HAH</searchLink>; School of Pharmacy, Newgiza University (NGU), Newgiza, km 22 Cairo- Alexandria Desert Road, Giza, 12577, Egypt.<br /><searchLink fieldCode="AU" term="%22El-Deeb+EM%22">El-Deeb EM</searchLink>; Pharmacognosy Department, Faculty of Pharmacy and drug technology, Egyptian Chinese University, Cairo, 11771, Egypt.<br /><searchLink fieldCode="AU" term="%22Saadeldeen+AM%22">Saadeldeen AM</searchLink>; Department of Pharmacognosy, School of Pharmacy, Newgiza University (NGU), Newgiza, km 22 Cairo-Alexandria Desert Road, Giza, 12577, Egypt.
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  Data: <searchLink fieldCode="JN" term="%22101563288%22">Scientific reports</searchLink> [Sci Rep] 2026 Jun 13; Vol. 16 (1). <i>Date of Electronic Publication: </i>2026 Jun 13.
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