From algorithm to verification: based on network toxicology and machine learning, the immunomodulatory role of IGFBP1/MKI67/C9 in perfluorooctanoic acid-induced osteoarthritis was discovered, and a diagnostic model was constructed.
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| Title: | From algorithm to verification: based on network toxicology and machine learning, the immunomodulatory role of IGFBP1/MKI67/C9 in perfluorooctanoic acid-induced osteoarthritis was discovered, and a diagnostic model was constructed. |
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| Authors: | Huang X; Department of Orthopedics, 3201 Hospital of Xi'an Jiaotong University Health Science Center, Hanzhong, China., Wei Y; Department of Orthopedics, 3201 Hospital of Xi'an Jiaotong University Health Science Center, Hanzhong, China., Rao Y; Department of Orthopedics, 3201 Hospital of Xi'an Jiaotong University Health Science Center, Hanzhong, China., Wei Y; The First Clinical Medical College of Yangtze University, Jingzhou, China., Chen H; Department of Laboratory, The First People's Hospital of Jingzhou (First Affiliated Hospital of Yangtze University), Jingzhou, China., Bao Y; The First Clinical Medical College of Yangtze University, Jingzhou, China.; Department of Orthopedics, The First People's Hospital of Jingzhou (First Affiliated Hospital of Yangtze University), Jingzhou, China. |
| Source: | Frontiers in immunology [Front Immunol] 2026 May 28; Vol. 17, pp. 1700638. Date of Electronic Publication: 2026 May 28 (Print Publication: 2026). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1664-3224 |
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| DOI: | 10.3389/fimmu.2026.1700638 |
