Pharmacology of nivegacetor (RG6289), a potent and selective gamma secretase modulator in clinical development for the treatment of Alzheimer's disease.
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| Title: | Pharmacology of nivegacetor (RG6289), a potent and selective gamma secretase modulator in clinical development for the treatment of Alzheimer's disease. |
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| Authors: | Lindemann L; Roche Pharma Research & Early Development, Neuroscience and Rare Diseases Translational Area, Discovery Neuroscience, F. Hoffmann-La Roche AG, Roche Innovation Center Basel, Basel, Switzerland., Lambotte J; Roche Pharma Research & Early Development, Neuroscience and Rare Diseases Translational Area, Discovery Neuroscience, F. Hoffmann-La Roche AG, Roche Innovation Center Basel, Basel, Switzerland., Rothe J; Roche Pharma Research & Early Development, Neuroscience and Rare Diseases Translational Area, Discovery Neuroscience, F. Hoffmann-La Roche AG, Roche Innovation Center Basel, Basel, Switzerland., Messer J; Roche Pharma Research & Early Development, Neuroscience and Rare Diseases Translational Area, Discovery Neuroscience, F. Hoffmann-La Roche AG, Roche Innovation Center Basel, Basel, Switzerland., Diener C; Roche Pharma Research & Early Development, Neuroscience and Rare Diseases Translational Area, Discovery Neuroscience, F. Hoffmann-La Roche AG, Roche Innovation Center Basel, Basel, Switzerland., Pichereau S; Roche Pharma Research & Early Development, Pharmaceutical Sciences, F. Hoffmann-La Roche AG, Roche Innovation Center Basel, Basel, Switzerland., Cantrill C; Roche Pharma Research & Early Development, Pharmaceutical Sciences, F. Hoffmann-La Roche AG, Roche Innovation Center Basel, Basel, Switzerland., Mueggler T; Roche Pharma Research & Early Development, Neuroscience and Rare Diseases Translational Area, Biomarkers, F. Hoffmann-La Roche AG, Roche Innovation Center Basel, Basel, Switzerland., Honer M; Roche Pharma Research & Early Development, Neuroscience and Rare Diseases Translational Area, Biomarkers, F. Hoffmann-La Roche AG, Roche Innovation Center Basel, Basel, Switzerland., Beck J; Roche Pharma Research & Early Development, Neuroscience and Rare Diseases Translational Area, Biomarkers, F. Hoffmann-La Roche AG, Roche Innovation Center Basel, Basel, Switzerland., Steinbrecher T; Roche Pharma Research & Early Development, Therapeutic Modalities, Small Molecules Research, Computer Aided Drug Design, F. Hoffmann-La Roche AG, Roche Innovation Center Basel, Basel, Switzerland., Tortelli R; Roche Pharma Research & Early Development, Neuroscience and Rare Diseases Translational Area, Early Clinical Development, F. Hoffmann-La Roche AG, Roche Innovation Center Basel, Basel, Switzerland., Gerlach I; Roche Pharma Research & Early Development, Neuroscience and Rare Diseases Translational Area, Early Clinical Development, F. Hoffmann-La Roche AG, Roche Innovation Center Basel, Basel, Switzerland., Ratni H; Roche Pharma Research & Early Development, Therapeutic Modalities, Small Molecules Research, Medicinal Chemistry, F. Hoffmann-La Roche AG, Roche Innovation Center Basel, Basel, Switzerland., Rodriguez Sarmiento RM; Roche Pharma Research & Early Development, Therapeutic Modalities, Small Molecules Research, Medicinal Chemistry, F. Hoffmann-La Roche AG, Roche Innovation Center Basel, Basel, Switzerland., Baumann K; Roche Pharma Research & Early Development, Neuroscience and Rare Diseases Translational Area, Discovery Neuroscience, F. Hoffmann-La Roche AG, Roche Innovation Center Basel, Basel, Switzerland. |
| Source: | Frontiers in pharmacology [Front Pharmacol] 2026 May 28; Vol. 17, pp. 1783414. Date of Electronic Publication: 2026 May 28 (Print Publication: 2026). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1663-9812 |
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| DOI: | 10.3389/fphar.2026.1783414 |
