An Antibacterial "Drug-Drug" Cocrystal of Trimethoprim with Sulfathiazole Achieving Synchronized Dual-Drug Release and Pharmacokinetics.

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Title: An Antibacterial "Drug-Drug" Cocrystal of Trimethoprim with Sulfathiazole Achieving Synchronized Dual-Drug Release and Pharmacokinetics.
Authors: Li WH; School of Pharmaceutical Sciences and Food Engineering, and State Key Laboratory of Macromolecular Drugs and Large-Scale Preparation, Liaocheng University, Liaocheng, Shandong 252059, PR China., Sun XH; School of Pharmaceutical Sciences and Food Engineering, and State Key Laboratory of Macromolecular Drugs and Large-Scale Preparation, Liaocheng University, Liaocheng, Shandong 252059, PR China., Chen X; School of Pharmaceutical Sciences and Food Engineering, and State Key Laboratory of Macromolecular Drugs and Large-Scale Preparation, Liaocheng University, Liaocheng, Shandong 252059, PR China., Gao SH; School of Pharmaceutical Sciences and Food Engineering, and State Key Laboratory of Macromolecular Drugs and Large-Scale Preparation, Liaocheng University, Liaocheng, Shandong 252059, PR China., Li FY; School of Pharmaceutical Sciences and Food Engineering, and State Key Laboratory of Macromolecular Drugs and Large-Scale Preparation, Liaocheng University, Liaocheng, Shandong 252059, PR China., Mo H; School of Pharmaceutical Sciences and Food Engineering, and State Key Laboratory of Macromolecular Drugs and Large-Scale Preparation, Liaocheng University, Liaocheng, Shandong 252059, PR China., Hu XY; School of Pharmaceutical Sciences and Food Engineering, and State Key Laboratory of Macromolecular Drugs and Large-Scale Preparation, Liaocheng University, Liaocheng, Shandong 252059, PR China., Wang XK; School of Pharmaceutical Sciences and Food Engineering, and State Key Laboratory of Macromolecular Drugs and Large-Scale Preparation, Liaocheng University, Liaocheng, Shandong 252059, PR China., Liu F; School of Pharmaceutical Sciences and Food Engineering, and State Key Laboratory of Macromolecular Drugs and Large-Scale Preparation, Liaocheng University, Liaocheng, Shandong 252059, PR China.
Source: ACS omega [ACS Omega] 2026 May 29; Vol. 11 (22), pp. 32732-32740. Date of Electronic Publication: 2026 May 29 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101691658 Publication Model: eCollection Cited Medium: Internet ISSN: 2470-1343 (Electronic) Linking ISSN: 24701343 NLM ISO Abbreviation: ACS Omega Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2470-1343
DOI:10.1021/acsomega.6c01610