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An Antibacterial "Drug-Drug" Cocrystal of Trimethoprim with Sulfathiazole Achieving Synchronized Dual-Drug Release and Pharmacokinetics.

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Title: An Antibacterial "Drug-Drug" Cocrystal of Trimethoprim with Sulfathiazole Achieving Synchronized Dual-Drug Release and Pharmacokinetics.
Authors: Li WH; School of Pharmaceutical Sciences and Food Engineering, and State Key Laboratory of Macromolecular Drugs and Large-Scale Preparation, Liaocheng University, Liaocheng, Shandong 252059, PR China., Sun XH; School of Pharmaceutical Sciences and Food Engineering, and State Key Laboratory of Macromolecular Drugs and Large-Scale Preparation, Liaocheng University, Liaocheng, Shandong 252059, PR China., Chen X; School of Pharmaceutical Sciences and Food Engineering, and State Key Laboratory of Macromolecular Drugs and Large-Scale Preparation, Liaocheng University, Liaocheng, Shandong 252059, PR China., Gao SH; School of Pharmaceutical Sciences and Food Engineering, and State Key Laboratory of Macromolecular Drugs and Large-Scale Preparation, Liaocheng University, Liaocheng, Shandong 252059, PR China., Li FY; School of Pharmaceutical Sciences and Food Engineering, and State Key Laboratory of Macromolecular Drugs and Large-Scale Preparation, Liaocheng University, Liaocheng, Shandong 252059, PR China., Mo H; School of Pharmaceutical Sciences and Food Engineering, and State Key Laboratory of Macromolecular Drugs and Large-Scale Preparation, Liaocheng University, Liaocheng, Shandong 252059, PR China., Hu XY; School of Pharmaceutical Sciences and Food Engineering, and State Key Laboratory of Macromolecular Drugs and Large-Scale Preparation, Liaocheng University, Liaocheng, Shandong 252059, PR China., Wang XK; School of Pharmaceutical Sciences and Food Engineering, and State Key Laboratory of Macromolecular Drugs and Large-Scale Preparation, Liaocheng University, Liaocheng, Shandong 252059, PR China., Liu F; School of Pharmaceutical Sciences and Food Engineering, and State Key Laboratory of Macromolecular Drugs and Large-Scale Preparation, Liaocheng University, Liaocheng, Shandong 252059, PR China.
Source: ACS omega [ACS Omega] 2026 May 29; Vol. 11 (22), pp. 32732-32740. Date of Electronic Publication: 2026 May 29 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101691658 Publication Model: eCollection Cited Medium: Internet ISSN: 2470-1343 (Electronic) Linking ISSN: 24701343 NLM ISO Abbreviation: ACS Omega Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: An Antibacterial "Drug-Drug" Cocrystal of Trimethoprim with Sulfathiazole Achieving Synchronized Dual-Drug Release and Pharmacokinetics.
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  Data: <searchLink fieldCode="AU" term="%22Li+WH%22">Li WH</searchLink>; School of Pharmaceutical Sciences and Food Engineering, and State Key Laboratory of Macromolecular Drugs and Large-Scale Preparation, Liaocheng University, Liaocheng, Shandong 252059, PR China.<br /><searchLink fieldCode="AU" term="%22Sun+XH%22">Sun XH</searchLink>; School of Pharmaceutical Sciences and Food Engineering, and State Key Laboratory of Macromolecular Drugs and Large-Scale Preparation, Liaocheng University, Liaocheng, Shandong 252059, PR China.<br /><searchLink fieldCode="AU" term="%22Chen+X%22">Chen X</searchLink>; School of Pharmaceutical Sciences and Food Engineering, and State Key Laboratory of Macromolecular Drugs and Large-Scale Preparation, Liaocheng University, Liaocheng, Shandong 252059, PR China.<br /><searchLink fieldCode="AU" term="%22Gao+SH%22">Gao SH</searchLink>; School of Pharmaceutical Sciences and Food Engineering, and State Key Laboratory of Macromolecular Drugs and Large-Scale Preparation, Liaocheng University, Liaocheng, Shandong 252059, PR China.<br /><searchLink fieldCode="AU" term="%22Li+FY%22">Li FY</searchLink>; School of Pharmaceutical Sciences and Food Engineering, and State Key Laboratory of Macromolecular Drugs and Large-Scale Preparation, Liaocheng University, Liaocheng, Shandong 252059, PR China.<br /><searchLink fieldCode="AU" term="%22Mo+H%22">Mo H</searchLink>; School of Pharmaceutical Sciences and Food Engineering, and State Key Laboratory of Macromolecular Drugs and Large-Scale Preparation, Liaocheng University, Liaocheng, Shandong 252059, PR China.<br /><searchLink fieldCode="AU" term="%22Hu+XY%22">Hu XY</searchLink>; School of Pharmaceutical Sciences and Food Engineering, and State Key Laboratory of Macromolecular Drugs and Large-Scale Preparation, Liaocheng University, Liaocheng, Shandong 252059, PR China.<br /><searchLink fieldCode="AU" term="%22Wang+XK%22">Wang XK</searchLink>; School of Pharmaceutical Sciences and Food Engineering, and State Key Laboratory of Macromolecular Drugs and Large-Scale Preparation, Liaocheng University, Liaocheng, Shandong 252059, PR China.<br /><searchLink fieldCode="AU" term="%22Liu+F%22">Liu F</searchLink>; School of Pharmaceutical Sciences and Food Engineering, and State Key Laboratory of Macromolecular Drugs and Large-Scale Preparation, Liaocheng University, Liaocheng, Shandong 252059, PR China.
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  Data: <searchLink fieldCode="JN" term="%22101691658%22">ACS omega</searchLink> [ACS Omega] 2026 May 29; Vol. 11 (22), pp. 32732-32740. <i>Date of Electronic Publication: </i>2026 May 29 (<i>Print Publication: </i>2026).
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              Text: 2026 May 29
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