Pancreatic islet α cell function and proliferation require the arginine transporter SLC7A2.
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| Title: | Pancreatic islet α cell function and proliferation require the arginine transporter SLC7A2. |
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| Authors: | Spears E; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Biology, Belmont University, Nashville, Tennessee, USA., Stanley JE; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, Tennessee, USA., Shou M; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Yin L; Department of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, Tennessee, USA., Li X; Department of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, Tennessee, USA., Dai C; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Bradley A; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Sellick K; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Poffenberger G; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Coate KC; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, Tennessee, USA., Shrestha S; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Schornack AMR; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Shepard T; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, Tennessee, USA., Wimalarathne M; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Jenkins R; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Sloop KW; Diabetes and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, USA., Wilson KT; Division of Gastroenterology, Hepatology & Nutrition, Department of Medicine.; Department of Pathology, Microbiology & Immunology.; Center for Mucosal Inflammation & Cancer; and.; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.; Veterans Affairs Tennessee Valley Healthcare System, Nashville, Tennessee, USA., Attie AD; Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA., Keller MP; Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA., Chen W; Department of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, Tennessee, USA., Powers AC; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, Tennessee, USA.; Veterans Affairs Tennessee Valley Healthcare System, Nashville, Tennessee, USA., Dean ED; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, Tennessee, USA. |
| Source: | The Journal of clinical investigation [J Clin Invest] 2026 Jun 15; Vol. 136 (12). Date of Electronic Publication: 2026 Jun 15 (Print Publication: 2026). |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: eCollection Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42294887 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Pancreatic islet α cell function and proliferation require the arginine transporter SLC7A2. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Spears+E%22">Spears E</searchLink>; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Biology, Belmont University, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Stanley+JE%22">Stanley JE</searchLink>; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Shou+M%22">Shou M</searchLink>; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Yin+L%22">Yin L</searchLink>; Department of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Department of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Dai+C%22">Dai C</searchLink>; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Bradley+A%22">Bradley A</searchLink>; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Sellick+K%22">Sellick K</searchLink>; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Poffenberger+G%22">Poffenberger G</searchLink>; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Coate+KC%22">Coate KC</searchLink>; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Shrestha+S%22">Shrestha S</searchLink>; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Schornack+AMR%22">Schornack AMR</searchLink>; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Shepard+T%22">Shepard T</searchLink>; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Wimalarathne+M%22">Wimalarathne M</searchLink>; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Jenkins+R%22">Jenkins R</searchLink>; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Sloop+KW%22">Sloop KW</searchLink>; Diabetes and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, USA.<br /><searchLink fieldCode="AU" term="%22Wilson+KT%22">Wilson KT</searchLink>; Division of Gastroenterology, Hepatology & Nutrition, Department of Medicine.; Department of Pathology, Microbiology & Immunology.; Center for Mucosal Inflammation & Cancer; and.; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.; Veterans Affairs Tennessee Valley Healthcare System, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Attie+AD%22">Attie AD</searchLink>; Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.<br /><searchLink fieldCode="AU" term="%22Keller+MP%22">Keller MP</searchLink>; Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.<br /><searchLink fieldCode="AU" term="%22Chen+W%22">Chen W</searchLink>; Department of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Powers+AC%22">Powers AC</searchLink>; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, Tennessee, USA.; Veterans Affairs Tennessee Valley Healthcare System, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Dean+ED%22">Dean ED</searchLink>; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, Tennessee, USA. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%227802877%22">The Journal of clinical investigation</searchLink> [J Clin Invest] 2026 Jun 15; Vol. 136 (12). <i>Date of Electronic Publication: </i>2026 Jun 15 (<i>Print Publication: </i>2026). – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Research Support, Non-U.S. Gov't – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Society+for+Clinical+Investigation%22">American Society for Clinical Investigation </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7802877 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1558-8238 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200219738%22">00219738 </searchLink><i>NLM ISO Abbreviation: </i>J Clin Invest <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42294887 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1172/JCI173913 Languages: – Code: eng Text: English Titles: – TitleFull: Pancreatic islet α cell function and proliferation require the arginine transporter SLC7A2. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Spears E – PersonEntity: Name: NameFull: Stanley JE – PersonEntity: Name: NameFull: Shou M – PersonEntity: Name: NameFull: Yin L – PersonEntity: Name: NameFull: Li X – PersonEntity: Name: NameFull: Dai C – PersonEntity: Name: NameFull: Bradley A – PersonEntity: Name: NameFull: Sellick K – PersonEntity: Name: NameFull: Poffenberger G – PersonEntity: Name: NameFull: Coate KC – PersonEntity: Name: NameFull: Shrestha S – PersonEntity: Name: NameFull: Schornack AMR – PersonEntity: Name: NameFull: Shepard T – PersonEntity: Name: NameFull: Wimalarathne M – PersonEntity: Name: NameFull: Jenkins R – PersonEntity: Name: NameFull: Sloop KW – PersonEntity: Name: NameFull: Wilson KT – PersonEntity: Name: NameFull: Attie AD – PersonEntity: Name: NameFull: Keller MP – PersonEntity: Name: NameFull: Chen W – PersonEntity: Name: NameFull: Powers AC – PersonEntity: Name: NameFull: Dean ED IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 06 Text: 2026 Jun 15 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1558-8238 Numbering: – Type: volume Value: 136 – Type: issue Value: 12 Titles: – TitleFull: The Journal of clinical investigation Type: main |
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