Resveratrol isomers with opposing activities target endonuclease G to modulate neurodegeneration and mitochondrial elimination.

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Title: Resveratrol isomers with opposing activities target endonuclease G to modulate neurodegeneration and mitochondrial elimination.
Authors: Lin JLJ; Institute of Molecular Biology, Academia Sinica, Taipei 11529, Taiwan., Wu X; Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309., Redweik GAJ; Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309., Chiu CC; Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Taoyuan 333, Taiwan.; Neuroscience Research Center, Chang Gung Memorial Hospital at Linkou, Taoyuan 333, Taiwan., Chiu TJ; Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Taoyuan 333, Taiwan., Chen YP; Institute of Molecular Biology, Academia Sinica, Taipei 11529, Taiwan., Webb KJ; Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309., Rani R; Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309., Lee ES; Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309., Yang WZ; Institute of Molecular Biology, Academia Sinica, Taipei 11529, Taiwan., Bhadra J; Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309., Stowell MHB; Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309., Yuan HS; Institute of Molecular Biology, Academia Sinica, Taipei 11529, Taiwan., Xue D; Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Jun 23; Vol. 123 (25), pp. e2534340123. Date of Electronic Publication: 2026 Jun 15.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1091-6490
DOI:10.1073/pnas.2534340123