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Resveratrol isomers with opposing activities target endonuclease G to modulate neurodegeneration and mitochondrial elimination.

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Title: Resveratrol isomers with opposing activities target endonuclease G to modulate neurodegeneration and mitochondrial elimination.
Authors: Lin JLJ; Institute of Molecular Biology, Academia Sinica, Taipei 11529, Taiwan., Wu X; Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309., Redweik GAJ; Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309., Chiu CC; Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Taoyuan 333, Taiwan.; Neuroscience Research Center, Chang Gung Memorial Hospital at Linkou, Taoyuan 333, Taiwan., Chiu TJ; Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Taoyuan 333, Taiwan., Chen YP; Institute of Molecular Biology, Academia Sinica, Taipei 11529, Taiwan., Webb KJ; Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309., Rani R; Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309., Lee ES; Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309., Yang WZ; Institute of Molecular Biology, Academia Sinica, Taipei 11529, Taiwan., Bhadra J; Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309., Stowell MHB; Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309., Yuan HS; Institute of Molecular Biology, Academia Sinica, Taipei 11529, Taiwan., Xue D; Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Jun 23; Vol. 123 (25), pp. e2534340123. Date of Electronic Publication: 2026 Jun 15.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: Resveratrol isomers with opposing activities target endonuclease G to modulate neurodegeneration and mitochondrial elimination.
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  Data: <searchLink fieldCode="AU" term="%22Lin+JLJ%22">Lin JLJ</searchLink>; Institute of Molecular Biology, Academia Sinica, Taipei 11529, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+X%22">Wu X</searchLink>; Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309.<br /><searchLink fieldCode="AU" term="%22Redweik+GAJ%22">Redweik GAJ</searchLink>; Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309.<br /><searchLink fieldCode="AU" term="%22Chiu+CC%22">Chiu CC</searchLink>; Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Taoyuan 333, Taiwan.; Neuroscience Research Center, Chang Gung Memorial Hospital at Linkou, Taoyuan 333, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chiu+TJ%22">Chiu TJ</searchLink>; Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Taoyuan 333, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+YP%22">Chen YP</searchLink>; Institute of Molecular Biology, Academia Sinica, Taipei 11529, Taiwan.<br /><searchLink fieldCode="AU" term="%22Webb+KJ%22">Webb KJ</searchLink>; Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309.<br /><searchLink fieldCode="AU" term="%22Rani+R%22">Rani R</searchLink>; Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309.<br /><searchLink fieldCode="AU" term="%22Lee+ES%22">Lee ES</searchLink>; Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309.<br /><searchLink fieldCode="AU" term="%22Yang+WZ%22">Yang WZ</searchLink>; Institute of Molecular Biology, Academia Sinica, Taipei 11529, Taiwan.<br /><searchLink fieldCode="AU" term="%22Bhadra+J%22">Bhadra J</searchLink>; Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309.<br /><searchLink fieldCode="AU" term="%22Stowell+MHB%22">Stowell MHB</searchLink>; Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309.<br /><searchLink fieldCode="AU" term="%22Yuan+HS%22">Yuan HS</searchLink>; Institute of Molecular Biology, Academia Sinica, Taipei 11529, Taiwan.<br /><searchLink fieldCode="AU" term="%22Xue+D%22">Xue D</searchLink>; Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309.
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  Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2026 Jun 23; Vol. 123 (25), pp. e2534340123. <i>Date of Electronic Publication: </i>2026 Jun 15.
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