Disruption of major Ptchd1 isoforms causes autistic traits in social behavior and communication.

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Title: Disruption of major Ptchd1 isoforms causes autistic traits in social behavior and communication.
Authors: Ko SY; Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada.; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Brain and Cognitive Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea., Pastore SF; Molecular Neuropsychiatry and Development Lab, Campbell Family Brain Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.; Institute of Medical Science, University of Toronto, Toronto, ON, Canada., Park S; Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada., Epp JR; Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada., Mikhailov A; Molecular Neuropsychiatry and Development Lab, Campbell Family Brain Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada., French L; Computational Neurobiology Lab, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada., Harada H; Donald K. Johnson Eye Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada., Monnier PP; Donald K. Johnson Eye Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada.; Department of Physiology, University of Toronto, Toronto, ON, M5S 1A8, Canada.; Department of Ophthalmology and Vision Science, University of Toronto, Toronto, ON, Canada., Hamel PA; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada., Josselyn SA; Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada.; Institute of Medical Science, University of Toronto, Toronto, ON, Canada.; Department of Physiology, University of Toronto, Toronto, ON, M5S 1A8, Canada.; Department of Psychology, University of Toronto, Toronto, ON, Canada., Vincent JB; Molecular Neuropsychiatry and Development Lab, Campbell Family Brain Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada. john.vincent@camh.ca.; Institute of Medical Science, University of Toronto, Toronto, ON, Canada. john.vincent@camh.ca.; Department of Psychiatry, University of Toronto, Toronto, ON, Canada. john.vincent@camh.ca., Frankland PW; Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada. paul.frankland@sickkids.ca.; Institute of Medical Science, University of Toronto, Toronto, ON, Canada. paul.frankland@sickkids.ca.; Department of Physiology, University of Toronto, Toronto, ON, M5S 1A8, Canada. paul.frankland@sickkids.ca.; Department of Psychology, University of Toronto, Toronto, ON, Canada. paul.frankland@sickkids.ca.; Child and Brain Development Program, Canadian Institute for Advanced Research, Toronto, ON, Canada. paul.frankland@sickkids.ca.
Source: Molecular psychiatry [Mol Psychiatry] 2026 Jun 16. Date of Electronic Publication: 2026 Jun 16.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-5578
DOI:10.1038/s41380-026-03685-2