Cathepsin L deletion enhances sensitivity to anticancer drugs through Parkin-mediated ubiquitination of Bcl-xL and USP53-induced Survivin destabilization.

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Title: Cathepsin L deletion enhances sensitivity to anticancer drugs through Parkin-mediated ubiquitination of Bcl-xL and USP53-induced Survivin destabilization.
Authors: Seo SU; Department of Immunology, School of Medicine, Keimyung University, Daegu, South Korea., Woo SM; Department of Immunology, School of Medicine, Keimyung University, Daegu, South Korea., Kwon Y; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South Korea., Kim S; Department of Immunology, School of Medicine, Keimyung University, Daegu, South Korea., Lee HS; KNU-Center for Nonlinear Dynamics, School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, College of Natural Sciences, Kyungpook National University, Daegu, South Korea., Kim SH; Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, South Korea., Min KJ; New Drug Discovery Center (NDDC), Daegu Gyeongbuk Medical Innovation Foundation (K-MEDI hub), Daegu, South Korea., Yook S; School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi, South Korea., Kwon TK; Department of Immunology, School of Medicine, Keimyung University, Daegu, South Korea. kwontk@dsmc.or.kr.; Center for Forensic Pharmaceutical Science, Keimyung University, Daegu, South Korea. kwontk@dsmc.or.kr.
Source: Cell death and differentiation [Cell Death Differ] 2026 Jun 15. Date of Electronic Publication: 2026 Jun 15.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9437445 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5403 (Electronic) Linking ISSN: 13509047 NLM ISO Abbreviation: Cell Death Differ Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1476-5403
DOI:10.1038/s41418-026-01783-w