Cathepsin L deletion enhances sensitivity to anticancer drugs through Parkin-mediated ubiquitination of Bcl-xL and USP53-induced Survivin destabilization.

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Title: Cathepsin L deletion enhances sensitivity to anticancer drugs through Parkin-mediated ubiquitination of Bcl-xL and USP53-induced Survivin destabilization.
Authors: Seo SU; Department of Immunology, School of Medicine, Keimyung University, Daegu, South Korea., Woo SM; Department of Immunology, School of Medicine, Keimyung University, Daegu, South Korea., Kwon Y; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South Korea., Kim S; Department of Immunology, School of Medicine, Keimyung University, Daegu, South Korea., Lee HS; KNU-Center for Nonlinear Dynamics, School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, College of Natural Sciences, Kyungpook National University, Daegu, South Korea., Kim SH; Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, South Korea., Min KJ; New Drug Discovery Center (NDDC), Daegu Gyeongbuk Medical Innovation Foundation (K-MEDI hub), Daegu, South Korea., Yook S; School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi, South Korea., Kwon TK; Department of Immunology, School of Medicine, Keimyung University, Daegu, South Korea. kwontk@dsmc.or.kr.; Center for Forensic Pharmaceutical Science, Keimyung University, Daegu, South Korea. kwontk@dsmc.or.kr.
Source: Cell death and differentiation [Cell Death Differ] 2026 Jun 15. Date of Electronic Publication: 2026 Jun 15.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9437445 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5403 (Electronic) Linking ISSN: 13509047 NLM ISO Abbreviation: Cell Death Differ Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Cathepsin L deletion enhances sensitivity to anticancer drugs through Parkin-mediated ubiquitination of Bcl-xL and USP53-induced Survivin destabilization.
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  Data: <searchLink fieldCode="AU" term="%22Seo+SU%22">Seo SU</searchLink>; Department of Immunology, School of Medicine, Keimyung University, Daegu, South Korea.<br /><searchLink fieldCode="AU" term="%22Woo+SM%22">Woo SM</searchLink>; Department of Immunology, School of Medicine, Keimyung University, Daegu, South Korea.<br /><searchLink fieldCode="AU" term="%22Kwon+Y%22">Kwon Y</searchLink>; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South Korea.<br /><searchLink fieldCode="AU" term="%22Kim+S%22">Kim S</searchLink>; Department of Immunology, School of Medicine, Keimyung University, Daegu, South Korea.<br /><searchLink fieldCode="AU" term="%22Lee+HS%22">Lee HS</searchLink>; KNU-Center for Nonlinear Dynamics, School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, College of Natural Sciences, Kyungpook National University, Daegu, South Korea.<br /><searchLink fieldCode="AU" term="%22Kim+SH%22">Kim SH</searchLink>; Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, South Korea.<br /><searchLink fieldCode="AU" term="%22Min+KJ%22">Min KJ</searchLink>; New Drug Discovery Center (NDDC), Daegu Gyeongbuk Medical Innovation Foundation (K-MEDI hub), Daegu, South Korea.<br /><searchLink fieldCode="AU" term="%22Yook+S%22">Yook S</searchLink>; School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi, South Korea.<br /><searchLink fieldCode="AU" term="%22Kwon+TK%22">Kwon TK</searchLink>; Department of Immunology, School of Medicine, Keimyung University, Daegu, South Korea. kwontk@dsmc.or.kr.; Center for Forensic Pharmaceutical Science, Keimyung University, Daegu, South Korea. kwontk@dsmc.or.kr.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9437445 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-5403 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2213509047%22">13509047 </searchLink><i>NLM ISO Abbreviation: </i>Cell Death Differ <i>Subsets: </i>MEDLINE
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        Value: 10.1038/s41418-026-01783-w
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      – Code: eng
        Text: English
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      – TitleFull: Cathepsin L deletion enhances sensitivity to anticancer drugs through Parkin-mediated ubiquitination of Bcl-xL and USP53-induced Survivin destabilization.
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            NameFull: Seo SU
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            NameFull: Woo SM
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            – D: 15
              M: 06
              Text: 2026 Jun 15
              Type: published
              Y: 2026
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